2.A.29.23.9 Mitochondrial transporter for 3′-phospho-adenosine 5′-phosphosulfate and adenosine 5′-phosphosulfate (APS), YPR011c. Sulfate and phosphate are also transported using an antiport mechanism (Todisco et al. 2014). Inhibited by bongkrekic acid. Deletion mutants are thermal sensitive and have less methionine and glutathione. The gene is induced by thermal stress conditions (Todisco et al. 2014).
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Accession Number: | Q12251 |
Protein Name: | Uncharacterized mitochondrial carrier YPR011C |
Length: | 326 |
Molecular Weight: | 35913.00 |
Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
Substrate |
phosphate(3-), sulfate, 5'-adenylyl sulfate, 3'-phospho-5'-adenylyl sulfate |
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1: MAEVLTVLEQ PNSIKDFLKQ DSNIAFLAGG VAGAVSRTVV SPFERVKILL QVQSSTTSYN
61: RGIFSSIRQV YHEEGTKGLF RGNGLNCIRI FPYSAVQFVV YEACKKKLFH VNGNNGQEQL
121: TNTQRLFSGA LCGGCSVVAT YPLDLIKTRL SIQTANLSSL NRSKAKSISK PPGIWQLLSE
181: TYRLEGGLRG LYRGVWPTSL GVVPYVALNF AVYEQLREFG VNSSDAQPSW KSNLYKLTIG
241: AISGGVAQTI TYPFDLLRRR FQVLAMGGNE LGFRYTSVWD ALVTIGRAEG VSGYYKGLAA
301: NLFKVVPSTA VSWLVYEVVC DSVRNW