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2.A.29.24.1
Brain mitochondrial carrier protein 1, BMCP1 (participates in mitochondrial proton leak) (also called uncoupling protein-5 (UCP5)) (Sanchis et al., 1998).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides similarly to UCP1-3 (Hoang et al. 2012); H+ transport may be activated while Cl- transport may be inhibited by faty acids (Hoang et al. 2015). Unc5 also transports sulfur anions (sulfate, sulfite, thiosulfate), inorganic phosphate, dicarboxylates (malonate, malate, citamalate, aspartate, gultamate) and tricarboxylates (Gorgoglione et al. 2019). It catalyzes fast anion:anion exchange and slow uniport. Sulfate and thiosulfate are the most high affinity substrates (Gorgoglione et al. 2019).

Accession Number:O95258
Protein Name:Brain mitochondrial carrier protein-1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25, member 14)
Length:325
Molecular Weight:36202.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate H+, Cl-

Cross database links:

RefSeq: NP_003942.1    NP_073721.1   
Entrez Gene ID: 9016   
Pfam: PF00153   
OMIM: 300242  gene
KEGG: hsa:9016    hsa:9016   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0009060 P:aerobic respiration
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport
GO:0005739 C:mitochondrion
GO:0006810 P:transport

References (10)

[1] “BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast.”  Sanchis D.et.al.   9852133
[2] “Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.”  Yu X.X.et.al.   10928996
[3] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[4] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast.”  Sanchis D.et.al.   9852133
[7] “Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.”  Yu X.X.et.al.   10928996
[8] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[9] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGIFPGIILI FLRVKFATAA VIVSGHQKST TVSHEMSGLN WKPFVYGGLA SIVAEFGTFP 
61:	VDLTKTRLQV QGQSIDARFK EIKYRGMFHA LFRICKEEGV LALYSGIAPA LLRQASYGTI 
121:	KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM 
181:	IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLILSGM MGDTILTHFV 
241:	SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTV DGILKMWKHE GFFALYKGFW 
301:	PNWLRLGPWN IIFFITYEQL KRLQI