Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.25.2
The mitochondrial carrier homologue-2 (MTCH2). Binds the BH3-interacting domain death agonist, BID. Regulated (induced) by the hepatocyte growth factor receptor, HGF/SF or Met. It has been proposed that its transport function has been lost (Robinson et al., 2012). Surprisingly, this protein has been reported to be targetted to the outer mitochondrial membrane (Gutiérrez-Aguilar and Baines, 2013).  MTCH2 is a mitochondrial outer membrane protein insertase (Guna et al. 2022). They are required for insertion of biophysically diverse tail-anchored (TA), signal-anchored, and multipass proteins, but not outer membrane beta-barrel proteins.

Accession Number:Q9Y6C9
Protein Name:Mitochondrial carrier homolog 2
Length:303
Molecular Weight:33331.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_055157.1   
Entrez Gene ID: 23788   
Pfam: PF00153   
OMIM: 613221  gene
KEGG: hsa:23788   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (5)

[1] “Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization.”  Yerushalmi G.M.et.al.   12407445
[2] “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.”  Zhang Q.-H.et.al.   11042152
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH 
61:	IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV 
121:	IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA 
181:	GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV 
241:	SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK 
301:	MLI