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Accession Number: | P55916 |
Protein Name: | Mitochondrial uncoupling protein 3 |
Length: | 312 |
Molecular Weight: | 34216.00 |
Species: | homo sapiens (Human) [9606] |
Location1 / Topology2 / Orientation3: | Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
Substrate | chloride, hydron |
Cross database links:
RefSeq: | NP_003347.1 NP_073714.1 |
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Entrez Gene ID: | 7352 |
Pfam: | PF00153 |
OMIM: |
601665 phenotype 602044 gene |
KEGG: | hsa:7352 hsa:7352 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005743
C:mitochondrial inner membrane
GO:0005488
F:binding
GO:0006839
P:mitochondrial transport
GO:0015992
P:proton transport
GO:0007585
P:respiratory gaseous exchange
GO:0055085
P:transmembrane transport
GO:0017077
F:oxidative phosphorylation uncoupler activity
GO:0005215
F:transporter activity
GO:0007568
P:aging
GO:0032870
P:cellular response to hormone stimulus
GO:0006631
P:fatty acid metabolic process
GO:0006629
P:lipid metabolic process
GO:0022904
P:respiratory electron transport chain
GO:0014823
P:response to activity
GO:0009409
P:response to cold
GO:0051384
P:response to glucocorticoid stimulus
GO:0001666
P:response to hypoxia
GO:0032868
P:response to insulin stimulus
GO:0007584
P:response to nutrient
GO:0000303
P:response to superoxide
GO:0044281
P:small molecule metabolic process
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References (16)[1] “Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.” Boss O.et.al. 9180264 [2] “The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.” Solanes G.et.al. 9325252 [3] “UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.” Vidal-Puig A.et.al. 9196039 [4] “Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin.” Gong D.-W.et.al. 9305858 [5] “Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.” Urhammer S.A.et.al. 9498661 [6] “The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents.” Esterbauer H.et.al. 10958796 [7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [8] “Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.” Argyropoulos G.et.al. 9769326 [9] “Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.” Boss O.et.al. 9180264 [10] “The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.” Solanes G.et.al. 9325252 [11] “UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.” Vidal-Puig A.et.al. 9196039 [12] “Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin.” Gong D.-W.et.al. 9305858 [13] “Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.” Urhammer S.A.et.al. 9498661 [14] “The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents.” Esterbauer H.et.al. 10958796 [15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [16] “Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.” Argyropoulos G.et.al. 9769326
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG 61: VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG ADNSSLTTRI 121: LAGCTTGAMA VTCAQPTDVV KVRFQASIHL GPSRSDRKYS GTMDAYRTIA REEGVRGLWK 181: GTLPNIMRNA IVNCAEVVTY DILKEKLLDY HLLTDNFPCH FVSAFGAGFC ATVVASPVDV 241: VKTRYMNSPP GQYFSPLDCM IKMVAQEGPT AFYKGFTPSF LRLGSWNVVM FVTYEQLKRA 301: LMKVQMLRES PF