TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.5.3
Mitochondrial iron transporter, mitoferrin (Shaw et al., 2006). Essential for erythroid iron utilization (Froschauer et al. 2009). Mitochondrial iron import regulation occurs through differential turnover of mitoferrin 1 and mitoferrin 2 (Paradkar et al., 2009)

Accession Number:Q287T7
Protein Name:Mitoferrin-1
Length:332
Molecular Weight:36711.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio) [7955]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate iron atom

Cross database links:

RefSeq: NP_001035060.1   
Entrez Gene ID: 387000   
Pfam: PF00153   
KEGG: dre:387000   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005381 F:iron ion transmembrane transporter activity
GO:0035162 P:embryonic hemopoiesis
GO:0043249 P:erythrocyte maturation
GO:0048250 P:mitochondrial iron ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Mitoferrin is essential for erythroid iron assimilation.”  Shaw G.C.et.al.   16511496

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MELRTDAVLA SLEMSEPVKN DEDYESLPAH ASLGTHMTAG AVAGILEHTV MYPVDSVKTR 
61:	MQSLQPDPKA QYRSVYGALK RIVRTEGLLR PLRGLNITVL GAGPAHALYF ACYERIKRSL 
121:	SDVIQNGGNS HIANGVAGSV ATVLHDAVMN PAEVVKQRMQ MYNSPYRSLY DCVLMVSRKE 
181:	GLAAFYRSYS TQLTMNIPFQ AVHFITYEFM QEHFNPHRQY RPETHIISGA AAGAVSAAVT 
241:	TPLDVCKTLL NTQENVALSS AHVSGHLSGM VNALRTVYRL GGVPAFFKGI QARVIYQMPS 
301:	TAIAWSVYEF FKYFLTQHES HVQEVSHKTS PT