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2.A.29.5.6
Solute carrier family 25, member 38, SLC25A38; probably involved in heme biosynthesis by importing glycine and/or 5-aminolevulinate into mitochondria (Gutiérrez-Aguilar and Baines 2013). SLC25A38 congenital sideroblastic anemia has been characterized with respect to their phenotypes and genotypes based on 31 individuals from 24 families (Heeney et al. 2021).

Accession Number:Q96DW6
Protein Name:Solute carrier family 25 member 38
Length:304
Molecular Weight:33566.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate 5-aminolevulinic acid, glycine

Cross database links:

Entrez Gene ID: 54977   
Pfam: PF00153   
KEGG: hsa:54977    hsa:54977   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0030218 P:erythrocyte differentiation
GO:0006783 P:heme biosynthetic process
GO:0006810 P:transport

References (8)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[4] “Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia.”  Guernsey D.L.et.al.   19412178
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[8] “Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia.”  Guernsey D.L.et.al.   19412178

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIQNSRPSLL QPQDVGDTVE TLMLHPVIKA FLCGSISGTC STLLFQPLDL LKTRLQTLQP 
61:	SDHGSRRVGM LAVLLKVVRT ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS LKQYFLRGHP 
121:	PTALESVMLG VGSRSVAGVC MSPITVIKTR YESGKYGYES IYAALRSIYH SEGHRGLFSG 
181:	LTATLLRDAP FSGIYLMFYN QTKNIVPHDQ VDATLIPITN FSCGIFAGIL ASLVTQPADV 
241:	IKTHMQLYPL KFQWIGQAVT LIFKDYGLRG FFQGGIPRAL RRTLMAAMAW TVYEEMMAKM 
301:	GLKS