2.A.29.6.2
Peroxysomal/glyoxysomal PMP38 (PXN) of 331 aas. Mediates NAD import into peroxisomes. Favors NAD (in)/AMP(out) antiport, but can also catalyze unidirectional transport that might be essential under special conditions. Transports CoA, dephospho-CoA, acetyl-CoA, adenosine 3'',5''-diphosphate (PAP), NAD , AMP, ADP and NADH, but not ATP, GTP, GDP, NADPH, NADP or FAD. Required for peroxisomeal proliferation (Mano et al. 2011; Agrimi et al. 2012; Bernhardt et al. 2012).
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| Accession Number: | O04200 |
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| Protein Name: | Peroxisomal nicotinamide adenine dinucleotide carrier |
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| Length: | 331 |
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| Molecular Weight: | 36213.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Glyoxysome membrane1 / Multi-pass membrane protein2 |
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| Substrate |
adenosine 5'-monophosphate, ADP, coenzyme A, acetyl-CoA, 3'-dephospho-CoA, adenosine 3',5'-bismonophosphate, NAD(+), NADH |
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1: MSDALINGLA GAGGGIIAQL LTYPLQTVNT RQQTERDLKR EKRKLGTIEH MCQVVKQEGW
61: ERLYGGLAPS LAGTAASQGV YYYFYQVFRN RAEATALARK KKGLGDGSVG MFASLLVAAF
121: AGSVNVLMTN PIWVIVTRMQ THRKMTKDQT AAPESPSSNA EALVAVEPRP YGTFNTIREV
181: YDEAGITGFW KGVIPTLIMV SNPSMQFMLY ETMLTKLKKK RALKGSNNVT ALETFLLGAV
241: AKLGATVTTY PLLVVKSRLQ AKQVTTGDKR QQYKGTLDAI LKMIRYEGLY GFYKGMSTKI
301: VQSVLAAAVL FMIKEELVKG AKLLLSNATS S