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Accession Number: | P53007 |
Protein Name: | Citrate carrier CIC (CTP) aka tricarboxylate carrier (citrate·H+/malate, PEP) (SLC25A1) |
Length: | 311 |
Molecular Weight: | 34013.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 5 |
Location1 / Topology2 / Orientation3: | Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
Substrate | hydron, phosphoenolpyruvate, citrate salt, malate(2-), cis-aconitate(3-), isocitrate(3-) |
Cross database links:
RefSeq: | NP_005975.1 |
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Entrez Gene ID: | 6576 |
Pfam: | PF00153 |
OMIM: |
190315 gene |
KEGG: | hsa:6576 hsa:6576 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005743
C:mitochondrial inner membrane
GO:0015137
F:citrate transmembrane transporter activity
GO:0005515
F:protein binding
GO:0006843
P:mitochondrial citrate transport
GO:0055085
P:transmembrane transport
GO:0006094
P:gluconeogenesis
GO:0035338
P:long-chain fatty-acyl-CoA biosynthetic process
GO:0019432
P:triglyceride biosynthetic process
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References (11)[1] “Localization of the human mitochondrial citrate transporter protein gene to chromosome 22q11 in the DiGeorge syndrome critical region.” Heisterkamp N.et.al. 8666394 [2] “Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region.” Goldmuntz E.et.al. 8660975 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 [6] “Localization of the human mitochondrial citrate transporter protein gene to chromosome 22q11 in the DiGeorge syndrome critical region.” Heisterkamp N.et.al. 8666394 [7] “Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region.” Goldmuntz E.et.al. 8660975 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MPAPRAPRAL AAAAPASGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK TQLQLDERSH 61: PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV RFGMFEFLSN HMRDAQGRLD 121: STRGLLCGLG AGVAEAVVVV CPMETIKVKF IHDQTSPNPK YRGFFHGVRE IVREQGLKGT 181: YQGLTATVLK QGSNQAIRFF VMTSLRNWYR GDNPNKPMNP LITGVFGAIA GAASVFGNTP 241: LDVIKTRMQG LEAHKYRNTW DCGLQILKKE GLKAFYKGTV PRLGRVCLDV AIVFVIYDEV 301: VKLLNKVWKT D