TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.9.2
Ornithine/arginine carrier, ORT1 or ARG11 (Palmieri et al., 1997).  Catalyzes H+:ornithine antiport for the export of ornithine from mitochondria (Palmieri et al. 2006).

Accession Number:Q12375
Protein Name:Mitochondrial ornithine carrier protein ORT1
Length:292
Molecular Weight:31580.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate ornithine, arginine

Cross database links:

DIP: DIP-8953N
RefSeq: NP_014773.1   
Entrez Gene ID: 854297   
Pfam: PF00153   
KEGG: sce:YOR130C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0000064 F:L-ornithine transmembrane transporter activity
GO:0006526 P:arginine biosynthetic process
GO:0000066 P:mitochondrial ornithine transport
GO:0055085 P:transmembrane transport

References (5)

[1] “The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis.”  Crabeel M.et.al.   8798783
[2] “Sequencing and analysis of 51 kb on the right arm of chromosome XV from Saccharomyces cerevisiae reveals 30 open reading frames.”  Wiemann S.et.al.   8904341
[3] “DNA sequencing and analysis of 130 kb from yeast chromosome XV.”  Voss H.et.al.   9200815
[4] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEDSKKKGLI EGAILDIING SIAGACGKVI EFPFDTVKVR LQTQASNVFP TTWSCIKFTY 
61:	QNEGIARGFF QGIASPLVGA CLENATLFVS YNQCSKFLEK HTNVFPLGQI LISGGVAGSC 
121:	ASLVLTPVEL VKCKLQVANL QVASAKTKHT KVLPTIKAII TERGLAGLWQ GQSGTFIRES 
181:	FGGVAWFATY EIVKKSLKDR HSLDDPKRDE SKIWELLISG GSAGLAFNAS IFPADTVKSV 
241:	MQTEHISLTN AVKKIFGKFG LKGFYRGLGI TLFRAVPANA AVFYIFETLS AL