2.A.32.1.1 Silicon transporter of 548 aas and 10 probable TMSs in a 2 + 3 + 2 + 3 TMS arrangement. It has a conserved aa motif, CMLD. Hydropathy profiles suggest that CMLD occupies a position between two TMSs. These two TMSs are candidates for a role of the channel through which transport of silicic acid occurs (Shcherbakova et al. 2006).
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Accession Number: | Q39510 |
Protein Name: | Sit1 |
Length: | 548 |
Molecular Weight: | 60572.00 |
Species: | Cylindrotheca fusiformis (Marine diatom) [2853] |
Number of TMSs: | 10 |
Location1 / Topology2 / Orientation3: |
Apical cell membrane1 / Multi-pass membrane protein2 |
Substrate |
silicon atom, silicate(4-) |
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Pfam: |
PF03842
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[1] “A gene family of silicon transporters.” Hildebrand M. et.al. 9034185
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1: MVSVIDGIKQ FYSMALVIFS VVIVTALMFT DNTKLAKDAH PVAALVIMWL GILWMSMVEG
61: GQCSMVGLPP IDRDLYKESH PITYKICSLG HKGNNLDRYL MGRQFMVIFI NFTINLCGAP
121: LEGAEVLGLP EILTDIFLGS GIAMVLTVVT IGQLTAQVNA SHCMLDYINT HFMTFTLYVT
181: LVIEATGVMH SCYLIRDMFY HAAGKPVETN EPPRSAVQNL FHWGRVVFSL GVLCFALAVT
241: IEALFNGKTT MWEFIPNGVA IVLFILLMSV VGLLEGMQIA FFAVAKIPKA ERGDHPFARK
301: TCELLFKGKG RNLPGFMVGR QMTVTLCFFI IARVTTLDIE VGVDDNIFGV SDGIQEFFNL
361: GFLGAIITTI LASIAWQLVA SAFPIAFLSN PIVYIVLRIV LLIEATGICA GAWFLGMIHK
421: KVAGFQLDEV YVGTAEERAA GMKPDHSIHA GREFTMGTNV LNDRKNWEET IANLSAKETF
481: SVRRERMLKN IRELRAMAEE ASSPEEKATF ETAPTMETKA LNKLNEEQEK EATLQKDSSD
541: TENEADLA