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2.A.4.1.4 Zn²⁺ (Km=105 μM), Cd²⁺ (Km=90 μM):proton (Km=20 nM) antiport metal ion efflux permease, ZitB (Chao and Fu, 2004a); Zn²⁺ (Km=1.4 μM; Anton et al., 2004). It also takes up Ni²⁺ and Cu²⁺ (Rahman et al., 2008).
Accession Number:	P75757
Protein Name:	ZitB
Length:	313
Molecular Weight:	34678.00
Species:	Escherichia coli [83333]
Number of TMSs:	5
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	cadmium(2+), zinc(2+), hydron

RefSeq:	AP_001383.1 NP_415273.1
Entrez Gene ID:	945348
Pfam:	PF01545
BioCyc:	EcoCyc:B0752-MONOMER ECOL168927:B0752-MONOMER
KEGG:	ecj:JW0735 eco:b0752
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0008324 F:cation transmembrane transporter activity GO:0055085 P:transmembrane transport GO:0006829 P:zinc ion transport
References (5) [1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “ZitB (YbgR), a member of the cation diffusion facilitator family, is an additional zinc transporter in Escherichia coli.” Grass G.et.al. 11443104 [5] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAHSHSHTSS HLPEDNNARR LLYAFGVTAG FMLVEVVGGF LSGSLALLAD AGHMLTDTAA 
61:	LLFALLAVQF SRRPPTIRHT FGWLRLTTLA AFVNAIALVV ITILIVWEAI ERFRTPRPVE 
121:	GGMMMAIAVA GLLANILSFW LLHHGSEEKN LNVRAAALHV LGDLLGSVGA IIAALIIIWT 
181:	GWTPADPILS ILVSLLVLRS AWRLLKDSVN ELLEGAPVSL DIAELKRRMC REIPEVRNVH 
241:	HVHVWMVGEK PVMTLHVQVI PPHDHDALLD QIQHYLMDHY QIEHATIQME YQPCHGPDCH 
301:	LNEGVSGHSH HHH

2.A.4.1.4
Zn²⁺ (Km=105 μM), Cd²⁺ (Km=90 μM):proton (Km=20 nM) antiport metal ion efflux permease, ZitB (Chao and Fu, 2004a); Zn²⁺ (Km=1.4 μM; Anton et al., 2004). It also takes up Ni²⁺ and Cu²⁺ (Rahman et al., 2008).

Cross database links:

Gene Ontology

References (5)

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2.A.4.1.4Zn2+ (Km=105 μM), Cd2+ (Km=90 μM):proton (Km=20 nM) antiport metal ion efflux permease, ZitB (Chao and Fu, 2004a); Zn2+ (Km=1.4 μM; Anton et al., 2004). It also takes up Ni2+ and Cu2+ (Rahman et al., 2008).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.4.1.4
Zn²⁺ (Km=105 μM), Cd²⁺ (Km=90 μM):proton (Km=20 nM) antiport metal ion efflux permease, ZitB (Chao and Fu, 2004a); Zn²⁺ (Km=1.4 μM; Anton et al., 2004). It also takes up Ni²⁺ and Cu²⁺ (Rahman et al., 2008).