2.A.42.1.2 High affinity (3 μM tryptophan permease, Mtr. Also transports indole. It functions to scavenge trace amounts of tryptophan in the medium for protein synthesis when concentrations are very low (Gu et al. 2013).
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Accession Number: | P0AAD2 |
Protein Name: | Tryptophan-specific transport protein Mtr aka B3161 |
Length: | 414 |
Molecular Weight: | 44333.00 |
Species: | Escherichia coli [83333] |
Number of TMSs: | 11 |
Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
Substrate |
tryptophan, 1H-indole |
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RefSeq: |
AP_003706.1
NP_417630.1
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Entrez Gene ID: |
947675
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Pfam: |
PF03222
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BioCyc: |
EcoCyc:MTR-MONOMER
ECOL168927:B3161-MONOMER
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KEGG: |
ecj:JW3130
eco:b3161
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[1] “Cloning, nucleotide sequence, and characterization of mtr, the structural gene for a tryptophan-specific permease of Escherichia coli K-12.” Heatwole V.M. et.al. 1987112
[2] “Regulation of expression of the Escherichia coli K-12 mtr gene by TyrR protein and Trp repressor.” Sarsero J.P. et.al. 2061290
[3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R. et.al. 9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K. et.al. 16738553
[5] “The tryptophan-specific permease gene, mtr, is differentially regulated by the tryptophan and tyrosine repressors in Escherichia coli K-12.” Heatwole V.M. et.al. 1904443
[6] “Membrane topology analysis of Escherichia coli K-12 Mtr permease by alkaline phosphatase and beta-galactosidase fusions.” Sarsero J.P. et.al. 7814318
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O. et.al. 15919996
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1: MATLTTTQTS PSLLGGVVII GGTIIGAGMF SLPVVMSGAW FFWSMAALIF TWFCMLHSGL
61: MILEANLNYR IGSSFDTITK DLLGKGWNVV NGISIAFVLY ILTYAYISAS GSILHHTFAE
121: MSLNVPARAA GFGFALLVAF VVWLSTKAVS RMTAIVLGAK VITFFLTFGS LLGHVQPATL
181: FNVAESNASY APYLLMTLPF CLASFGYHGN VPSLMKYYGK DPKTIVKCLV YGTLMALALY
241: TIWLLATMGN IPRPEFIGIA EKGGNIDVLV QALSGVLNSR SLDLLLVVFS NFAVASSFLG
301: VTLGLFDYLA DLFGFDDSAV GRLKTALLTF APPVVGGLLF PNGFLYAIGY AGLAATIWAA
361: IVPALLARAS RKRFGSPKFR VWGGKPMIAL ILVFGVGNAL VHILSSFNLL PVYQ