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2.A.42.1.3 Low affinity (70 μM) tryptophan permease, coregulated with the enzyme tryptophanase. It functions in tryptohan degradation, yielding carbon and nitrogen (Gu et al. 2013).
Accession Number:	P23173
Protein Name:	TnaB aka TRPP aka B3709
Length:	415
Molecular Weight:	45211.00
Species:	Escherichia coli [83333]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	tryptophan

RefSeq:	AP_004080.1 AP_004082.1 NP_418165.1
Entrez Gene ID:	948220
Pfam:	PF03222
BioCyc:	EcoCyc:TNAB-MONOMER ECOL168927:B3709-MONOMER
KEGG:	eco:b3709
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0006865 P:amino acid transport GO:0006569 P:tryptophan catabolic process
References (6) [1] “A new family of integral membrane proteins involved in transport of aromatic amino acids in Escherichia coli.” Sarsero J.P.et.al. 2022620 [2] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.” Burland V.D.et.al. 7686882 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Nucleotide sequence of the structural gene for tryptophanase of Escherichia coli K-12.” Deeley M.C.et.al. 6268608 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MTDQAEKKHS AFWGVMVIAG TVIGGGMFAL PVDLAGAWFF WGAFILIIAW FSMLHSGLLL 
61:	LEANLNYPVG SSFNTITKDL IGNTWNIISG ITVAFVLYIL TYAYISANGA IISETISMNL 
121:	GYHANPRIVG ICTAIFVASV LWLSSLAASR ITSLFLGLKI ISFVIVFGSF FFQVDYSILR 
181:	DATSSTAGTS YFPYIFMALP VCLASFGFHG NIPSLIICYG KRKDKLIKSV VFGSLLALVI 
241:	YLFWLYCTMG NIPRESFKAI ISSGGNVDSL VKSFLGTKQH GIIEFCLLVF SNLAVASSFF 
301:	GVTLGLFDYL ADLFKIDNSH GGRFKTVLLT FLPPALLYLI FPNGFIYGIG GAGLCATIWA 
361:	VIIPAVLAIK ARKKFPNQMF TVWGGNLIPA IVILFGITVI LCWFGNVFNV LPKFG

2.A.42.1.3
Low affinity (70 μM) tryptophan permease, coregulated with the enzyme tryptophanase. It functions in tryptohan degradation, yielding carbon and nitrogen (Gu et al. 2013).

Cross database links:

Gene Ontology

References (6)

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Analyze:

2.A.42.1.3Low affinity (70 μM) tryptophan permease, coregulated with the enzyme tryptophanase. It functions in tryptohan degradation, yielding carbon and nitrogen (Gu et al. 2013).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.42.1.3
Low affinity (70 μM) tryptophan permease, coregulated with the enzyme tryptophanase. It functions in tryptohan degradation, yielding carbon and nitrogen (Gu et al. 2013).