TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.45.1.1









Arsenical resistance efflux pump (exports As(III) and Sb(III) probably as polymers of the hydroxides using an H+ antiport mechanism) (Meng et al., 2004)
Bacteria
Bacillota
ArsB of Staphylococcus aureus
2.A.45.1.2









Arsenic transporter, ArsB, of 422 aas and 11 TMSs.

Bacteria
Campylobacterota
ArsB of Campylobacter coli
2.A.45.2.1









P-protein; possible tyrosine transporter (also called "melanocyte-specific transporter", "oculocutaneous albinism-related protein (Oca2)" and "pink-eyed dilution gene product").  It has been reported to exhibit chloride-selective anion channel activity and to be required for melanin production, possibly by controling melanosome pH (Bellono et al. 2014). Its function has been reviewed (Wiriyasermkul et al. 2020).

Eukaryota
Metazoa, Chordata
P-protein of Homo sapiens
2.A.45.2.2









Uncharacterized transporter Mb2703
Bacteria
Actinomycetota
Mb2703 of Mycobacterium bovis
2.A.45.2.3









Putative ion transporter in magnetosome membranes of magentotactic bacteria, MamN of 437 aas and 10 TMSs (Murat et al. 2010). Uebe and Schüler 2016 considered that MamN might be a proton exporter that releases H+ from the magentosome matrix to the cytosol. 

Bacteria
Pseudomonadota
MamN of Magnetospirillum gryphiswaldense
2.A.45.2.4









The plasma membrane silicon (silicate) efflux pump, Low Silicon 2, Lsi2 (localized to the proximal side of the cell, whereas the silicon uptake system, Lsi1 (TC# 1.A.8.12.2) is localized to the distal side of the same cells) (Ma et al., 2007a, b). It has 472 aas and 10 TMSs in a 5 + 5 TMS arrangement.

Eukaryota
Viridiplantae, Streptophyta
Lsi2 of Oryza sativa
(Q10SY9)
2.A.45.2.5









Inner membrane protein YbiR
Bacteria
Pseudomonadota
YBIR of Escherichia coli K-12
2.A.45.2.6









Putative plasma membrane low silicon efflux pump, Lsi2, of 393 aas and 12 TMSs.

Bacteria
Actinomycetota
Lsi2 of Bifidobacterium asteroides
2.A.45.2.7









Citrate transporter, OsCT1 of 567 aas and 12 TMSs in a 3 + 1 + 1 + 1 + 3 + 1 + 1 + 1 TMS arrangement. It differs from previously known plant citrate transporters and is structurally close to rice silicon transporters (Panchal et al. 2023). OsCT1 carries a bacterial citrate-metal transporter domain, CitMHS. and showed citrate efflux activity when expressed in Xenopus laevis oocytes, being localized to the cell plasma membrane. It is highly expressed in the shoots and reproductive tissues of rice, and its promoter activity was visible in cells surrounding the vasculature. The OsCT1 knockout (KO) lines showed a reduced citrate content in the shoots and the root exudates, whereas the overexpression (OE) line showed higher citrate exudation from their roots. Further, the KO and OE lines showed variations in the manganese (Mn) distribution as expected if citrate and Mn2+ were co-transported.

Eukaryota
Viridiplantae, Streptophyta
OsCT1 of Oryza sativa Japonica Group (Japanese rice)
2.A.45.3.1









Putative transporter of 461 aas and 14 TMSs in a 3 + 3 + 1 + 3 + 3 + 1 TMS arrangement.

Bacteria
Bacillota
Putative transporter of Bacillus cereus (gi 30021968)
2.A.45.3.2









Uncharaterized protein of 570 aas and 14 TMSs in a 7 + 7 arrangement.

Bacteria
Actinomycetota
UP of Nocardioides sp.