2.A.48.1.3
The folate transporter, FolT-1 of 453 aas, with a Km for folate of 1.2μM and a Ki for Sulfasalazine of 0.1 mM. Folt-1 also transports reduced folate and substituted folate derivatives.  The system is maximally expressed in the pharynx and intestine, and it is developmentallyl regulated. DIDS, a general anion inhibitor, also inhibits (Balamurugan et al., 2007).  FOLT-1 function affects both the soma and the germline. folt-1(ok1460) hermaphrodites suffer severely diminished lifespan and germline defects that result in sterility. Germline defects associated with folate deficiency appear widespread in animals, being found in humans, mice, fruit flies, and nematodes (Austin et al. 2010).