2.A.49.2.13
Clh-3; Clc-3, Clh3, Clc3 of 1001 aas and 11 TMSs. Isoform a: Voltage-gated chloride channel (Rutledge et al. 2002; Denton et al. 2005).
Insensitive to depolarizing voltages; requires low
voltages for activation; insensitive to chloride levels but has a mild
sensitivity to low pH. Channel gating properties are conferred by the
cytoplasmic C-terminus (He et al. 2006).
Plays a role in egg laying by modulating hermaphrodite-specific neuron excitability and the ovulatory contractions of
gap-junction-coupled gonadal sheath cells (Branicky et al. 2014). When active, may prevent tubular formation of the excretory canals (Hisamoto et al. 2008). Activated during oocyte meiotic maturation and by membrane hyperpolarization and cell swelling (Denton et al. 2004). Inhibited by Zn2+ and to a lesser extent by Cd2+(Rutledge et al. 2001). Isoform b: Voltage-gated chloride channel sensitive to depolarizing conditioning voltages; requires stronger
voltages for activation and activation is slower, is inhibited by low
concentrations of chloride and is activated by low pH. Channel gating
properties are conferred by the cytoplasmic C-terminus (He et al. 2006).
|
| Accession Number: | Q9BMK9 |
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| Protein Name: | Chloride channel protein clh-3 |
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| Length: | 1001 |
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| Molecular Weight: | 110787.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride |
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1: MGIGTKILSK IEKNKTSDGL TIPLTPTTQK QSSSWCSFES IKTFFRTVIR DWIFLALLGF
61: IMASLSFGMD YAILNLQNGQ MRLFDLVKEY HFTLAYLVWV GYVVGLILLS AVCAHYIAPQ
121: AIGSGIPEMK TILRGVILKE YLSVRTLLSK MIGLTLSLGS GLPMGKEGPF VHVASVVASQ
181: LTRLVHGSSG GIFENESRSG EMLAAGCAVG VACTFSAPIG GVLFSIEVTS VYFAVRNYWR
241: GFFAATCSAT LFRILRMFSV SAAVTVEAHY QTNFPPQNVF LPQELPIFAL IGLVCGLAGS
301: IFVYLHRRTV LFLRRNWLAK MIFQKYWLIY PIFIATFISS LSFPLGLGKF MGGEERFSHT
361: MKEFFVDCAW TAPPNDSYAC PMPTSNATSS DSFDIRHWKG DNYDYSPFVT LSSFQVVYFF
421: LAILASTLPV PSGIFMPVFV LGAAFGRLVG EGVFSLDPYG HISGDIQFFV RPGVYAVVGA
481: AAFCGAVTHT VSVAVIVFEL TGQLCHLLPV MIAVLIANAV ASYLQPSIYD SIIRIKNLPY
541: LPDIPHTTSL YHQMLIEQFM ISPLVYIAKD STVGDIKRAL ETKTRIRAFP LVENMESLAL
601: VGSVSRSQLQ RYVDSQIGTK ARFAEATRRI KQRLEDEESE RKRREESKSD DTEDSLETTG
661: AGERRASRFL IVPVAKNGPQ VAKNETLTGL SEENARKILT VEEKQALFDA ASLATPKREM
721: SGKTINPVHI ESHHTIGDIF RSITHLSFGR QNFPKKNNHN EFDLFGEERT EWEDMMLNQK
781: LDLSQLDIDS TPFQLSEYTS LFKAHSLFSL LGLNRAYVTK KGQLIGVVAL KELRLAIEYL
841: QSGKVPTPGM SIFNEPPTEQ SIYEKSARLE SGRATGDAQN AAFVTDNGED DAQNDYIQPP
901: LEVVRRGALT PNRMSELTRL ENVRTTPESP HFEVSSPSTS SSCVSIDFSP LDAANSENGS
961: VGGLVLNVPS LPTRARSANE LTRQNTHVQI NLPDDVHDEK F