2.A.49.2.14
The voltage-gated chloride channel, CLCNKB, CLCCK or CLC-Kb of 687 aas and 10 TMSs in a 2 + 2 + 2 + 2 + 2 arrangement. These anion channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. It may also be important in urinary concentrating mechanisms (Estévez et al. 2001). Inactivated variants in the CLCNKB gene, encoding the basolateral chloride channel ClC-Kb cause classic Bartter syndrome, characterized by hypokalemic metabolic alkalosis and hyperreninemic hyperaldosteronism (Wang et al. 2018).