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2.A.49.2.14
The voltage-gated chloride channel, CLCNKB, CLCCK or CLC-Kb of 687 aas and 10 TMSs in a 2 + 2 + 2 + 2 + 2 arrangement. These anion channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. It may also be important in urinary concentrating mechanisms (Estévez et al. 2001). Inactivated variants in the CLCNKB gene, encoding the basolateral chloride channel ClC-Kb cause classic Bartter syndrome, characterized by hypokalemic metabolic alkalosis and hyperreninemic hyperaldosteronism (Wang et al. 2018).

Accession Number:C4IN73
Protein Name:FapF
Length:430
Molecular Weight:46467.00
Species:Pseudomonas sp. UK4 [452680]
Number of TMSs:1
Substrate

Cross database links:

Structure:
5O65   5O67   5O68   6FUE     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHRSLSLRAV VCLSTLLPAS LLYAAPDVDI ETLKQELLEL KQRYEAQQKA LAVLEQRVRQ 
61:	VEDQPATPAP KRLAKSPADF KQSGSTVAAS SGTGGATGGS SYGQSLKDDS EPAQSVSNLY 
121:	NEASGFFGNG KFSFETGITY ARYDARQLTL NGFLALDSIF LGNINLDRIK ADNWTLDLTG 
181:	RYNLDNRWQF DVNVPVVYRE STYQSGGASG GDPQATSEES VSRDPTIGDV NFGIAYKFLD 
241:	ESATMPDAVV SVRVKAPTGK EPFGIKLVRS TANDNLYVPE SLPTGNGVWS ITPGLSLVKT 
301:	FDPAVLFGSV SYTHNLEDSF DDISSDVNQK VGGKVRLGDS FQFGVGVAFA LNERMSMSFS 
361:	VSDLIQRKSK LKPDGGGWQS IVSSDANAGY FNVGMTIAAS ENLTIVPNLA IGMTDDAPDF 
421:	TFSLKFPYYF