2.A.49.2.15
Chloride channel protein, CLCNKB or ClC-Kb or CLCKB of 687 aas and 10 TMSs in a 2 + 2 + 2 + 2 + 2 TMS arrangement. Voltage-gated chloride channel. Chloride channels have several functions
including the regulation of cell volume; membrane potential
stabilization, signal transduction and transepithelial transport. May be
important in urinary concentrating mechanisms (Estévez et al. 2001). CLCNKB Complex Heterozygous Mutations play a role in Adult-Onset Type III Bartter Syndrome (Chen and Hong 2024).
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| Accession Number: | P51801 |
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| Protein Name: | Chloride channel protein ClC-Kb |
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| Length: | 687 |
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| Molecular Weight: | 75446.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
anion, chloride |
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1: MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW YFLMTLGVLM
61: ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPSSGG
121: SGIPEVKTML AGVVLEDYLD IKNFGAKVVG LSCTLACGST LFLGKVGPFV HLSVMMAAYL
181: GRVRTTTIGE PENKSKQNEM LVAAAAVGVA TVFAAPFSGV LFSIEVMSSH FSVWDYWRGF
241: FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FRVDVPFDLP EIFFFVALGG LCGILGSAYL
301: FCQRIFFGFI RNNRFSSKLL ATSKPVYSAL ATLVLASITY PPSAGRFLAS RLSMKQHLDS
361: LFDNHSWALM TQNSSPPWPE ELDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP
421: MPAGYFMPIF VYGAAIGRLF GETLSFIFPE GIVAGGITNP IMPGGYALAG AAAFSGAVTH
481: TISTALLAFE VTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTVIVKKLP YLPRILGRNI
541: GSHRVRVEHF MNHSITTLAK DMPLEEVVKV VTSTDVAKYP LVESTESQIL VGIVRRAQLV
601: QALKAEPPSW APGHQQCLQD ILAAGCPTEP VTLKLSPETS LHEAHNLFEL LNLHSLFVTS
661: RGRAVGCVSW VEMKKAISNL TNPPAPK