2.A.49.2.16
H+/Cl- exchange transporter 5, ClC-5 (CLCN5; CLCK2) of 816 aas and 12 TMSs in a 1 + 1 + 2 + 2 + 2 + 2 + 2 TMS arrangement. It functions as antiport system and exchanges chloride ions against protons (Neagoe et al. 2010). ClC-5 is expressed in the apical membrane of cyst epithelia and is a likely candidate mediating Cl- secretion into the kidney cyst lumen in the tuberous sclerosis complex (TSC) (Barone et al. 2022).
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| Accession Number: | P51795 |
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| Protein Name: | H(+)/Cl(-) exchange transporter 5 |
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| Length: | 816 |
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| Molecular Weight: | 90785.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride, hydron |
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1: MAMWQGAMDN RGFQQGSFSS FQNSSSDEDL MDIPATAMDF SMRDDVPPLD REVGEDKSYN
61: GGGIGSSNRI MDFLEEPIPG VGTYDDFNTI DWVREKSRDR DRHREITNKS KESTWALIHS
121: VSDAFSGWLL MLLIGLLSGS LAGLIDISAH WMTDLKEGIC TGGFWFNHEH CCWNSEHVTF
181: EERDKCPEWN SWSQLIISTD EGAFAYIVNY FMYVLWALLF AFLAVSLVKV FAPYACGSGI
241: PEIKTILSGF IIRGYLGKWT LVIKTITLVL AVSSGLSLGK EGPLVHVACC CGNILCHCFN
301: KYRKNEAKRR EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF
361: TLRSINPFGN SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT
421: QLGKYPVIEV LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL CDYENRFNTS
481: KGGELPDRPA GVGVYSAMWQ LALTLILKIV ITIFTFGMKI PSGLFIPSMA VGAIAGRLLG
541: VGMEQLAYYH QEWTVFNSWC SQGADCITPG LYAMVGAAAC LGGVTRMTVS LVVIMFELTG
601: GLEYIVPLMA AAMTSKWVAD ALGREGIYDA HIRLNGYPFL EAKEEFAHKT LAMDVMKPRR
661: NDPLLTVLTQ DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK
721: QDGVVSTSII YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ
781: CLVTHNGRLL GIITKKDVLK HIAQMANQDP DSILFN