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2.A.49.2.16
H+/Cl- exchange transporter 5, ClC-5 (CLCN5; CLCK2) of 816 aas and 12 TMSs in a 1 + 1 + 2 + 2 + 2 + 2 + 2 TMS arrangement. It functions as antiport system and exchanges chloride ions against protons (Neagoe et al. 2010). ClC-5 is expressed in the apical membrane of cyst epithelia and is a likely candidate mediating Cl- secretion into the kidney cyst lumen in the tuberous sclerosis complex (TSC) (Barone et al. 2022).

Accession Number:P51795
Protein Name:H(+)/Cl(-) exchange transporter 5
Length:816
Molecular Weight:90785.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate chloride, hydron

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMWQGAMDN RGFQQGSFSS FQNSSSDEDL MDIPATAMDF SMRDDVPPLD REVGEDKSYN 
61:	GGGIGSSNRI MDFLEEPIPG VGTYDDFNTI DWVREKSRDR DRHREITNKS KESTWALIHS 
121:	VSDAFSGWLL MLLIGLLSGS LAGLIDISAH WMTDLKEGIC TGGFWFNHEH CCWNSEHVTF 
181:	EERDKCPEWN SWSQLIISTD EGAFAYIVNY FMYVLWALLF AFLAVSLVKV FAPYACGSGI 
241:	PEIKTILSGF IIRGYLGKWT LVIKTITLVL AVSSGLSLGK EGPLVHVACC CGNILCHCFN 
301:	KYRKNEAKRR EVLSAAAAAG VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF 
361:	TLRSINPFGN SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT 
421:	QLGKYPVIEV LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL CDYENRFNTS 
481:	KGGELPDRPA GVGVYSAMWQ LALTLILKIV ITIFTFGMKI PSGLFIPSMA VGAIAGRLLG 
541:	VGMEQLAYYH QEWTVFNSWC SQGADCITPG LYAMVGAAAC LGGVTRMTVS LVVIMFELTG 
601:	GLEYIVPLMA AAMTSKWVAD ALGREGIYDA HIRLNGYPFL EAKEEFAHKT LAMDVMKPRR 
661:	NDPLLTVLTQ DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK 
721:	QDGVVSTSII YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ 
781:	CLVTHNGRLL GIITKKDVLK HIAQMANQDP DSILFN