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2.A.49.2.5 The kidney thick ascending limb of Henle's loop and collecting duct chloride channel/carrier, ClC-K2 (Br^- > I^- > Cl^- >> cyclamate) (Adachi et al., 1994). Regulated by the accessory subunit, Barttin (Wojciechowski et al. 2015).
Accession Number:	P51802
Protein Name:	Chloride channel protein ClC-Kb aka ClC-K2
Length:	687
Molecular Weight:	75218.00
Species:	Rattus norvegicus (Rat) [10116]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	chloride, bromide, iodide, Cyclamate

RefSeq:	NP_775126.1
Entrez Gene ID:	79430
Pfam:	PF00571 PF00654
KEGG:	rno:79430
Gene Ontology GO:0034707 C:chloride channel complex GO:0000139 C:Golgi membrane GO:0005886 C:plasma membrane GO:0005247 F:voltage-gated chloride channel activity GO:0030321 P:transepithelial chloride transport GO:0055085 P:transmembrane transport
References (4) [1] “Two highly homologous members of the ClC chloride channel family in both rat and human kidney.” Kieferle S.et.al. 8041726 [2] “Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney.” Adachi S.et.al. 8021279 [3] “Barttin increases surface expression and changes current properties of ClC-K channels.” Waldegger S.et.al. 12111250 [4] “Molecular mechanisms of Bartter syndrome caused by mutations in the BSND gene.” Hayama A.et.al. 12761627

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEEIVGLREG SPRKPVPLQE LWRPCPRIRR NIQGSLEWLK ERLFRVGEDW YFLVALGVLM 
61:	ALISYAMNFA IGRVVRAHKW LYREIGDGHL LRYLSWTVYP VALLSFSSGF SQSITPSSGG 
121:	SGIPEVKTIL TGVILEDYLD IKNFGAKVVG LSCTLATGST IFLGKLGPFV HLSVMIAAYL 
181:	GRVRTKTVGE PENKTKEMEL LAAGAAVGVA TVFAAPISGV LFSIEVMSSH FSVWDYWRGF 
241:	FAATCGAFMF HLLAVFNSEQ ETITSIYKTS FPVDIPFDLP EIFFFVALGA ICGILSCGYN 
301:	YCQRTSLFFL KSNGFTSKLL ATSKPLYSAL AAVVLASITY PPGVGRFMAS RLSMSEYLET 
361:	LFDNNSWALM TKNSSPPWSA EPDPQNLWLE WCHPQMTVFG TLVFFLVMKF WMLILATTIP 
421:	IPAGYFLPIF VYGAAIGRLF GEVLSLAFPE GIVAGGKVSP IMPGAYALAG AAAFSGAVTH 
481:	TLSTALLAFE VSGQIVHALP VLMAVLAANA ICQSYQPSFY DGTIIVKKLP YLPWIRGRKI 
541:	GSHLVTVGHF MNCTLTTLAK DMPLEEVIKV VISTDVTQYP LVETTESQVL VGIVKRTHLV 
601:	QSLHTDSASW APGQQPCLQD ILANGCPTQP VTLQLSTETS LHETHNLFEL LNLQLLFVTS 
661:	RGRAVGSVSW VELKKAISTL TNPPAPK

2.A.49.2.5
The kidney thick ascending limb of Henle's loop and collecting duct chloride channel/carrier, ClC-K2 (Br^- > I^- > Cl^- >> cyclamate) (Adachi et al., 1994). Regulated by the accessory subunit, Barttin (Wojciechowski et al. 2015).

Cross database links:

Gene Ontology

References (4)

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2.A.49.2.5The kidney thick ascending limb of Henle's loop and collecting duct chloride channel/carrier, ClC-K2 (Br- > I- > Cl- >> cyclamate) (Adachi et al., 1994). Regulated by the accessory subunit, Barttin (Wojciechowski et al. 2015).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.49.2.5
The kidney thick ascending limb of Henle's loop and collecting duct chloride channel/carrier, ClC-K2 (Br^- > I^- > Cl^- >> cyclamate) (Adachi et al., 1994). Regulated by the accessory subunit, Barttin (Wojciechowski et al. 2015).