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2.A.49.2.7 The ClC-A of the trophozoite plasma membrane (Cl^->Br^->I^->F^->NO₃^- ). Functions as an ion channel, not a Cl:H⁺ antiporter; regulates cell pH and volume (Salas-Casas et al., 2006)
Accession Number:	Q70S43
Protein Name:	Chloride channel type CLC aka clcA
Length:	668
Molecular Weight:	74520.00
Species:	Entamoeba histolytica [5759]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	fluoride, chloride, bromide, iodide, nitrate

RefSeq:	XP_651175.2
Entrez Gene ID:	3405494
Pfam:	PF00654
KEGG:	ehi:EHI_142170
Gene Ontology GO:0016021 C:integral to membrane GO:0005247 F:voltage-gated chloride channel activity GO:0006821 P:chloride transport GO:0055085 P:transmembrane transport
References (2) [1] “Identification and functional characterization of EhClC-A, an Entamoeba histolytica ClC chloride channel located at plasma membrane.” Salas-Casas A.et.al. 16430698 [2] “The genome of the protist parasite Entamoeba histolytica.” Loftus B.J.et.al. 15729342

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	METTHPLSSS PFTQDNTFEL FEIDDLEDGN NDIDNVLVKI QTDPTQNSFL VHHENKYLKL 
61:	IKRICLFQVF GYKGTLIHVV AFYLFLLGVV SAVIGVSMDI TVEKLQDLRL WLCSLVENSF 
121:	YKVIIWVIYT IVLVTMAFLW TKFISPTANG SGVPEMKVTL LGNRIPNLLT FKTLIAKVIG 
181:	LVFVLGGGMW AGKEGPFIHI SSCIASQLTR LPIFRFLRNS NELFMQMLST ATSCGVSSNF 
241:	GTAIGGLLFS VEVTATYFSV RNYWFGTFSS VIAAFTFRAI FNTYSHSPSL YSGLLSIDYS 
301:	FPSLQIKDSL ISILLGVICG LFAVLFVMSV STIFKTRQYL RKYKLGRIPY LYLVIVALFT 
361:	GVVTAPWYGE LSPFGYPTYT TLSQMYTNSS VKPLFGKHYL FALFLLFIAR FTITAMSISM 
421:	PVPVGLFSTN IVVGSVLGRF IGECFSVWGI SNNLGPSGMA IIGGACFVGS ITQTFSAAVI 
481:	MIELIDDISI LVPMLIATVI TICFSRFFTV CVYDKIAIDK KLPYIPDIQY SSNQTAEMVM 
541:	DTNLVLISEY TNLVDLKEIV DQFQTLPDKI LPVVNDLEHS VLLGQVKLSV LRKLLDAQIP 
601:	EHVANKFLLD YSECPLHLLR HTPLSQIHML FIAAEIDSAF VTSNGRLIGE INKKCLTEAI 
661:	NKQMKILF

2.A.49.2.7
The ClC-A of the trophozoite plasma membrane (Cl^->Br^->I^->F^->NO₃^- ). Functions as an ion channel, not a Cl:H⁺ antiporter; regulates cell pH and volume (Salas-Casas et al., 2006)

Cross database links:

Gene Ontology

References (2)

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2.A.49.2.7The ClC-A of the trophozoite plasma membrane (Cl->Br->I->F->NO3- ). Functions as an ion channel, not a Cl:H+ antiporter; regulates cell pH and volume (Salas-Casas et al., 2006)

Cross database links:

Gene Ontology

References (2)

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2.A.49.2.7
The ClC-A of the trophozoite plasma membrane (Cl^->Br^->I^->F^->NO₃^- ). Functions as an ion channel, not a Cl:H⁺ antiporter; regulates cell pH and volume (Salas-Casas et al., 2006)