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2.A.49.2.8
ClC-4 or CLCN4 (catalyzes 2 Cl-:H+ exchange, but NO3- uniport (Bergsdorf et al., 2009). SCN- uncouples Cl- from H+ transport so anions are transported with high unitary transport rates. Voltage then influences transport as is observed for the gating of ion channels (Orhan et al., 2011). Also transports bromide and iodide.

Accession Number:P51793
Protein Name:Chloride channel protein 4
Length:760
Molecular Weight:84917.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Early endosome membrane1 / Multi-pass membrane protein2
Substrate chloride, hydron

Cross database links:

RefSeq: NP_001821.2   
Entrez Gene ID: 1183   
Pfam: PF00571    PF00654   
OMIM: 302910  gene
KEGG: hsa:1183   

Gene Ontology

GO:0031901 C:early endosome membrane
GO:0016021 C:integral to membrane
GO:0031902 C:late endosome membrane
GO:0015297 F:antiporter activity
GO:0005524 F:ATP binding
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport
GO:0055085 P:transmembrane transport

References (3)

[1] “A gene from the Xp22.3 region shares homology with voltage-gated chloride channels.”  van Slegtenhorst M.A.et.al.   8069296
[2] “Identification of an acid-activated Cl- channel from human skeletal muscles.”  Kawasaki M.et.al.   10564087
[3] “Determinants of anion-proton coupling in mammalian endosomal CLC proteins.”  Zdebik A.A.et.al.   18063579

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT SKSKESIWEF 
61:	IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE GVCLSAFWYS HEQCCWTSNE 
121:	TTFEDRDKCP LWQKWSELLV NQSEGASAYI LNYLMYILWA LLFAFLAVSL VRVFAPYACG 
181:	SGIPEIKTIL SGFIIRGYLG KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS 
241:	LFSKYSKNEG KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV 
301:	AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI RCNIAWCRRR 
361:	KTTRLGKYPV LEVIVVTAIT AIIAYPNPYT RQSTSELISE LFNDCGALES SQLCDYINDP 
421:	NMTRPVDDIP DRPAGVGVYT AMWQLALALI FKIVVTIFTF GMKIPSGLFI PSMAVGAIAG 
481:	RMVGIGVEQL AYHHHDWIIF RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF 
541:	ELTGGLEYIV PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM 
601:	RPRRGEPPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSR DSERLIGFAQ RRELILAIKN 
661:	ARQRQEGIVS NSIMYFTEEP PELPANSPHP LKLRRILNLS PFTVTDHTPM ETVVDIFRKL 
721:	GLRQCLVTRS GRLLGIITKK DVLRHMAQMA NQDPESIMFN