2.A.5.1.1
High affinity zinc-regulated zinc uptake transporter, Zrt1 of 376 aas and 8 TMSs. May be a transceptor with both transport and receptor (signal transduction) functions (Diallinas 2017; Schothorst et al. 2017). Activated at the transcriptional level by Yap1 and Ace1 (Gomes et al. 2005). Zrt1 may also transport, or influence the uptake of Cd2+ (Gomes et al. 2005).
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| Accession Number: | P32804 |
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| Protein Name: | Zrt1 aka YGL255W aka NRC376 |
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| Length: | 376 |
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| Molecular Weight: | 41582.00 |
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| Species: | Saccharomyces cerevisiae (Baker's yeast) [4932] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
cadmium(2+), zinc(2+) |
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| RefSeq: |
NP_011259.1
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| Entrez Gene ID: |
852637
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| Pfam: |
PF02535
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| KEGG: |
sce:YGL255W
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[1] “Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae.” Breitwieser W. et.al. 8322518
[2] “Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae.” Coissac E. et.al. 8972578
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.” Tettelin H. et.al. 9169869
[4] “The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae.” Zhao H. et.al. 8798516
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1: MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR ISSVFVILFV
61: STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF IHLMDPAYGA IGGTTCVGQT
121: GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW VERKYGLSHD HTHDEIKDTV VRNTAAVSSE
181: NDNENGTANG SHDTKNGVEY YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL
241: GSVGDEFSSL YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG
301: LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK DLRELSFNVI
361: CTLFGAGIMA LIGKWA