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2.A.5.1.2
Iron regulated Fit1-mediated plasma membrane high affinity Fe2+ uptake transporter, Irt1, of 347 aas and 9 TMSs (also takes up Co2+, Mn2+, Zn2+ and possibly Cd2+) (Korshunova et al., 1999; Schaaf et al., 2006; Halimaa et al. 2014).  It is targetted to the plasma membrane by Sorting nexin1 (Snx1; Q9FG38) (Ivanov et al. 2014). Root-to-shoot iron partitioning in Arabidopsis requires the IRON-REGULATED TRANSPORTER1 (IRT1) protein but not its iron(II) transport function (Quintana et al. 2022).

Accession Number:Q38856
Protein Name:Irt1 aka T16H5.50 aka AT4G19690
Length:339
Molecular Weight:35939.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cadmium(2+), cobalt(2+), iron(2+), zinc(2+), manganese(2+)

Cross database links:

RefSeq: NP_849546.1   
Entrez Gene ID: 827713   
Pfam: PF02535   
BioCyc: MetaCyc:AT4G19690-MONOMER   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015088 F:copper uptake transmembrane transporter act...
GO:0005381 F:iron ion transmembrane transporter activity
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006826 P:iron ion transport
GO:0009617 P:response to bacterium
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (6)

[1] “A novel iron-regulated metal transporter from plants identified by functional expression in yeast.”  Eide D.et.al.   8643627
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[3] “Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins.”  Eng B.H.et.al.   9784581
[4] “The IRT1 protein from Arabidopsis thaliana is a metal transporter with a broad substrate range.”  Korshunova Y.O.et.al.   10394943
[5] “Altered selectivity in an Arabidopsis metal transporter.”  Rogers E.E.et.al.   11035780
[6] “IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth.”  Vert G.et.al.   12084823

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKTIFLVLIF VSFAISPATS TAPEECGSES ANPCVNKAKA LPLKVIAIFV ILIASMIGVG 
61:	APLFSRNVSF LQPDGNIFTI IKCFASGIIL GTGFMHVLPD SFEMLSSICL EENPWHKFPF 
121:	SGFLAMLSGL ITLAIDSMAT SLYTSKNAVG IMPHGHGHGH GPANDVTLPI KEDDSSNAQL 
181:	LRYRVIAMVL ELGIIVHSVV IGLSLGATSD TCTIKGLIAA LCFHQMFEGM GLGGCILQAE 
241:	YTNMKKFVMA FFFAVTTPFG IALGIALSTV YQDNSPKALI TVGLLNACSA GLLIYMALVD 
301:	LLAAEFMGPK LQGSIKMQFK CLIAALLGCG GMSIIAKWA