2.A.5.1.21
Zinc-regulated zinc transporting Zrt2 of 370 aas and 8 TMSs in a 3 + 5 TMS arrangement. It contains an extra-membrane disordered loop, corresponding to the amino acid sequence 126-215. Three Zrt2+ regions in this loop bind Zn2+ and Cu2+ with comparable affinities below pH 5, and therefore, may equally contribute to metal acquisition under the most acidic conditions in which the Zrt2 transporter is expressed (Bellotti et al. 2022).
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| Accession Number: | B9WAU5 |
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| Protein Name: | Zinc-regulated transporter, putative |
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| Length: | 370 |
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| Molecular Weight: | 41167.00 |
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| Species: | Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast) [573826] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
zinc(2+) |
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1: MNSDSISRVF EYLNKRDECP TDNDYNGNIG TRVSSIFVIM VTSAIGTLLP LLSSKYSFIR
61: LPPMVYFICK YFGSGVIVAT AFIHLLEPAA DSLGNECLTG PITDYPWAFG ICLMTLFLLF
121: FFELLAYQGI DRKIAKESQL DNQGAHTHSH FGDASMYVKK DDVEEDLENQ DEKNTDSNPY
181: PSHFAHAQEH QDPDVMGTAV NDQSKEQYYG QLIGVFVLEF GVMFHSVFIG LALAVSGDEF
241: KSLYIVLVFH QMFEGLGLGT RIATTNWSRH RYTPWILAIC YTLCTPIAIA VGLGVRKSYP
301: PGSRRALITN GVFDSISAGI LLYTGIVELM AHEFLYSGEF KGPGGFKNML LAYFVMCWGA
361: GLMALLGKWA