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2.A.5.1.4
Iron-regulated Fit1-mediated (coregulated with Irt1) vacuolar high-affinity Fe2+ efflux (from the vacuole into the cytoplasm) transporter, Irt2 (also transports Zn2+ (Schaaf et al., 2006). The archetypical IRT proteins from angiosperms likely emerged before the origin of land plants during early streptophyte algae terrestrialization, a process that required the evolution of Fe acquisition in terrestrial subaerial settings (Rodrigues et al. 2023).

Accession Number:O81850
Protein Name:Irt2
Length:350
Molecular Weight:37407.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate iron(2+), zinc(2+)

Cross database links:

RefSeq: NP_001031670.1    NP_193703.2   
Entrez Gene ID: 827712   
Pfam: PF02535   
BioCyc: MetaCyc:AT4G19680-MONOMER   
KEGG: ath:AT4G19680   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005381 F:iron ion transmembrane transporter activity
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006826 P:iron ion transport
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (3)

[1] “Arabidopsis IRT2 gene encodes a root-periphery iron transporter.”  Vert G.et.al.   11389759
[2] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[3] “Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis.”  Wintz H.et.al.   13129917

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MATTKLVYIL LILFTFTVSP AISTAPEHCD SGFDNPCINK AKALPLKIVA IVAILTTSLI 
61:	GVTSPLFSRY ISFLRPDGNG FMIVKCFSSG IILGTGFMHV LPDSFEMLSS KCLSDNPWHK 
121:	FPFAGFVAMM SGLVTLAIDS ITTSLYTGKN SVGPVPDEEY GIDQEKAIHM VGHNHSHGHG 
181:	VVLATKDDGQ LLRYQVIAMV LEVGILFHSV VIGLSLGATN DSCTIKGLII ALCFHHLFEG 
241:	IGLGGCILQA DFTNVKKFLM AFFFTGTTPC GIFLGIALSS IYRDNSPTAL ITIGLLNACS 
301:	AGMLIYMALV DLLATEFMGS MLQGSIKLQI KCFTAALLGC AVMSVVAVWA