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2.A.5.4.10
Zn2+ transporter, Zip5 (540aas; 1+3+3 TMSs; processed to a 3+3 TMS protein) (Basolateral membrane; carries out serosal to mucosal transport).  Xenotransplanted human organoids identify transepithelial zinc transports, SLC39A4 and A5, as two mediators of intestinal adaptation (Sampah et al. 2024).

Accession Number:Q6ZMH5
Protein Name:Zinc transporter ZIP5
Length:539
Molecular Weight:56330.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate zinc(2+)

Cross database links:

Entrez Gene ID: 283375   
Pfam: PF02535   
KEGG: hsa:283375    hsa:283375   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0034224 P:cellular response to zinc ion starvation

References (6)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.”  Wang F.et.al.   15322118
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.”  Wang F.et.al.   15322118

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGSPVSHLLA GFCVWVVLGW VGGSVPNLGP AEQEQNHYLA QLFGLYGENG TLTAGGLARL 
61:	LHSLGLGRVQ GLRLGQHGPL TGRAASPAAD NSTHRPQNPE LSVDVWAGMP LGPSGWGDLE 
121:	ESKAPHLPRG PAPSGLDLLH RLLLLDHSLA DHLNEDCLNG SQLLVNFGLS PAAPLTPRQF 
181:	ALLCPALLYQ IDSRVCIGAP APAPPGDLLS ALLQSALAVL LLSLPSPLSL LLLRLLGPRL 
241:	LRPLLGFLGA LAVGTLCGDA LLHLLPHAQE GRHAGPGGLP EKDLGPGLSV LGGLFLLFVL 
301:	ENMLGLLRHR GLRPRCCRRK RRNLETRNLD PENGSGMALQ PLQAAPEPGA QGQREKNSQH 
361:	PPALAPPGHQ GHSHGHQGGT DITWMVLLGD GLHNLTDGLA IGAAFSDGFS SGLSTTLAVF 
421:	CHELPHELGD FAMLLQSGLS FRRLLLLSLV SGALGLGGAV LGVGLSLGPV PLTPWVFGVT 
481:	AGVFLYVALV DMLPALLRPP EPLPTPHVLL QGLGLLLGGG LMLAITLLEE RLLPVTTEG