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2.A.5.4.8 The divalent cation (M²⁺): bicarbonate (HCO₃^-) transporter (M²⁺:HCO₃^- = 1:2). Transports Cd²⁺ and Zn²⁺, and probably Cu²⁺, Pb²⁺, and Hg²⁺ (based on competitive inhibition studies (Liu et al., 2008))
Accession Number:	Q91W10
Protein Name:	Zip8
Length:	462
Molecular Weight:	50082.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	7
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	metal cation, cadmium(2+), lead(2+), copper(2+), mercury(2+), zinc(2+), hydrogencarbonate

RefSeq:	NP_001128621.1 NP_001128622.1 NP_080504.3
Entrez Gene ID:	67547
Pfam:	PF02535
KEGG:	mmu:67547
Gene Ontology GO:0016021 C:integral to membrane GO:0046873 F:metal ion transmembrane transporter activity GO:0055085 P:transmembrane transport GO:0006829 P:zinc ion transport
References (2) [1] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAPGRAVAGL LLLAATSLGH PSEGPELAFS EDVLSVFGAN RSLSAAQLGR LLERLGAASQ 
61:	QGALDLGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFSAI CPAILQQLNF HPCEDLRKHN 
121:	AKPSLSEVWG YGFLSVTIIN LASLLGLILT PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ 
181:	LIPEAFGFNP KIDNYVEKAV AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE 
241:	KTHQPKTLPL PAVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKTEPSS CTCLKGPKLS 
301:	EIGTIAWMIT LCDALHNFID GLAIGASCTL SLLQGLSTSI AILCEEFPHE LGDFVILLNA 
361:	GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL AGGMFLYISL ADMFPEMNDM 
421:	LREKVTGRQT DFTFFMIQNA GMLTGFTAIL LITLYAGDIE LQ

2.A.5.4.8
The divalent cation (M²⁺): bicarbonate (HCO₃^-) transporter (M²⁺:HCO₃^- = 1:2). Transports Cd²⁺ and Zn²⁺, and probably Cu²⁺, Pb²⁺, and Hg²⁺ (based on competitive inhibition studies (Liu et al., 2008))

Cross database links:

Gene Ontology

References (2)

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2.A.5.4.8The divalent cation (M2+): bicarbonate (HCO3-) transporter (M2+:HCO3- = 1:2). Transports Cd2+ and Zn2+, and probably Cu2+, Pb2+, and Hg2+ (based on competitive inhibition studies (Liu et al., 2008))

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.5.4.8
The divalent cation (M²⁺): bicarbonate (HCO₃^-) transporter (M²⁺:HCO₃^- = 1:2). Transports Cd²⁺ and Zn²⁺, and probably Cu²⁺, Pb²⁺, and Hg²⁺ (based on competitive inhibition studies (Liu et al., 2008))