2.A.5.5.2
Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11). In mice, Zip11 mRNA is abundantly expressed in testes and the digestive system
including stomach, ileum and cecum. Analysis of cellular zinc content,
metallothionein levels, and cell viability under high or low zinc
conditions in cells transfected with a murine Zip11 expression plasmid,
suggest that Zip11 is a zinc importer (Yu et al. 2013). ZIP11 may have a zinc and iron binuclear transport center for iorn and zinc (Roberts et al. 2021).
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| Accession Number: | Q8N1S5 |
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| Protein Name: | Zinc transporter ZIP11 |
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| Length: | 342 |
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| Molecular Weight: | 35396.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
|
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| Entrez Gene ID: |
201266
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| Pfam: |
PF02535
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| KEGG: |
hsa:201266
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[1] “Comparative genomics of the SOX9 region in human and Fugu rubripes: conservation of short regulatory sequence elements within large intergenic regions.” Bagheri-Fam S. et.al. 11707075
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T. et.al. 14702039
[3] “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.” Zody M.C. et.al. 16625196
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
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1: MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV MLAASYWSLL
61: APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGAAEDPQT TLALNFGSTL
121: MKKKSDPEGP ALLFPESELS IRIGRAGLLS DKSENGEAYQ RKKAAATGLP EGPAVPVPSR
181: GNLAQPGGSS WRRIALLILA ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ
241: NFPEGLAVSL PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG
301: AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG