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2.A.50.1.1
Putative glycerol:H+ symporter of 546 aas and 12 TMSs, GUP1.  In yeast, Gup1 is associated with a high number and diversity of biological functions, namely polarity establishment, secretory/endocytic pathway functionality, vacuole morphology, wall and membrane composition, structure and maintenance, cell death, morphogenesis and differentiation (Lucas et al. 2016). The protein HHAT (Hedgehog O-acyltransferase) modifies Hh morphogens prior to their secretion, while HHATL (Hh O-acyltransferase-like) negatively regulates the pathway. HHAT and HHATL are homologous to Saccharomyces cerevisiae Gup2 and Gup1, respectively (Lucas et al. 2016).

Accession Number:P53154
Protein Name:YG14 aka GUP1 aka YGL084C
Length:560
Molecular Weight:65340.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate hydron, glycerol

Cross database links:

DIP: DIP-4367N
RefSeq: NP_011431.1   
Entrez Gene ID: 852796   
Pfam: PF03062   
KEGG: sce:YGL084C   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008374 F:O-acyltransferase activity
GO:0005515 F:protein binding
GO:0015293 F:symporter activity
GO:0019563 P:glycerol catabolic process
GO:0015793 P:glycerol transport
GO:0006506 P:GPI anchor biosynthetic process

References (6)

[1] “Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII.”  Rieger M.et.al.   9290212
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[3] “GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae.”  Holst B.et.al.   10931309
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[6] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLISILSPL ITSEGLDSRI KPSPKKDAST TTKPSLWKTT EFKFYYIAFL VVVPLMFYAG 
61:	LQASSPENPN YARYERLLSQ GWLFGRKVDN SDSQYRFFRD NFALLSVLML VHTSIKRIVL 
121:	YSTNITKLRF DLIFGLIFLV AAHGVNSIRI LAHMLILYAI AHVLKNFRRI ATISIWIYGI 
181:	STLFINDNFR AYPFGNICSF LSPLDHWYRG IIPRWDVFFN FTLLRVLSYN LDFLERWENL 
241:	QKKKSPSYES KEAKSAILLN ERARLTAAHP IQDYSLMNYI AYVTYTPLFI AGPIITFNDY 
301:	VYQSKHTLPS INFKFIFYYA VRFVIALLSM EFILHFLHVV AISKTKAWEN DTPFQISMIG 
361:	LFNLNIIWLK LLIPWRLFRL WALLDGIDTP ENMIRCVDNN YSSLAFWRAW HRSYNKWVVR 
421:	YIYIPLGGSK NRVLTSLAVF SFVAIWHDIE LKLLLWGWLI VLFLLPEIFA TQIFSHYTDA 
481:	VWYRHVCAVG AVFNIWVMMI ANLFGFCLGS DGTKKLLSDM FCTVSGFKFV ILASVSLFIA 
541:	VQIMFEIREE EKRHGIYLKC