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|---|---|
| Accession Number: | Q8BMT9 |
| Protein Name: | Protein-cysteine N-palmitoyltransferase HHAT |
| Length: | 499 |
| Molecular Weight: | 57864.00 |
| Species: | Mus musculus (Mouse) [10090] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | glycerol |
Cross database links:
| Entrez Gene ID: | 226861 |
|---|---|
| Pfam: | PF03062 |
| KEGG: | mmu:226861 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0016021
C:integral to membrane
GO:0005525
F:GTP binding
GO:0016409
F:palmitoyltransferase activity
GO:0007275
P:multicellular organismal development
GO:0018345
P:protein palmitoylation
GO:0007224
P:smoothened signaling pathway
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References (5)[1] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.” Church D.M.et.al. 19468303 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.” Chen M.-H.et.al. 15075292 [5] “Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.” Abe Y.et.al. 18081866
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MLPGWELTLC LLVSLGFHFR SFYEVYKVSR EHEEELDQEF ELEMDTLFGG LKKDPTDFEW 61: NFWMEWGKRR LVWLFIGHMA VSQLATLLTK KHRPWIVMVY GMWACWCVLG APGVVMVLLH 121: STIAFCVAQF RSVLLSWLCS LLLLSTLRLQ SVEEVKRRWY KTENEYYLLQ FTLTVRCLYY 181: TSFSLELCRQ PPSAQPTPSA QGASHSYPWL LTYVFYYPVF HNGPILNFPE FFRQMQQPEL 241: NSLQHSLCIV AKGLGRLLCW WWLAELMVHL MYMHALYSSA PLLESVSCWT LGGLALAQVL 301: FFYVKYLVLF GVPALLMRLD GLTPPPLPRC VSTMFSFTGM WRYFDVGLHN FLIRYVYIPL 361: GGSQHGLLGT LLSTATTFAF VSYWHGSYED LWCWAALNWL GVTVESGVRR LLETPCVRET 421: LARHLSPQAH HRLHALLAAC STSMLILFNL VFLGGIQVGK TYWNRIFLQG WPWVTLSVLG 481: FLYCYSHVDI AWAQTYTVL