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2.A.50.1.5
Skinny or Sightless (Rasp, Cmn, Sit, Ski) of 500 aas and 12 TMSs.  It is required in hedgehog (hh) expressing cells for production of appropriate signaling activity in embryos and in the imaginal precursors of adult tissues. It acts within the secretory pathway to catalyze N-terminal palmitoylation of Hh; this lipid modification is required for the embryonic and larval patterning activities of the Hh signal, but is not required for Wg signaling (Chamoun et al. 2001; Lee and Treisman 2001).

Accession Number:Q9VZU2
Protein Name:Protein-cysteine N-palmitoyltransferase Rasp
Length:500
Molecular Weight:58106.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MSRLPDRSLL TRCEIFVYFG VYIAYIVVGL YKIYGLRDHI VKEAKFQFPE GWSLYPFSQR 
61:	RRDDSNDELE NFGDFIVSFW PFYLLHVAVQ GFIRWKRPRL QCLGFIGVCA LALSVNLDWS 
121:	SMVLLVTLIA SYYIVSLLSL KFLVWLLSAG WILCINVMQK NVWWTDRVGY TEYVLVIVTM 
181:	SWSVLRGCSY SLSKIGAKQE DLTRYSLVQY LGYAMYFPCL TYGPIISYQR FAARREDEVQ 
241:	NWLGFVGGVL RSAIWWLVMQ CALHYFYIHY MSRDVRMVEM MDSVFWQHSA GYFMGQFFFL 
301:	YYVVTYGLGI AFAVQDGIPA PNRPRCIGRI HFYSDMWKYF DEGLYEFLFQ NIYAELCGKR 
361:	SSAAAKFGAT ALTFAFVFVW HGCYTYVLIW SILNFLCLAA EKVFKTFTAM PEYQRWTQRH 
421:	LGAVGAQRLY AMLATQLFIP AAFSNVYFIG GQEIGDFLMR GAYLSGVGNY VALCFCSYCF 
481:	FQCSELLLTK SDGRSKTKTF