2.A.50.2.5 MBOAT7, also called BB1, LENG4, OCT7, of 472 aas and possibly 12 TMSs as 3 sets of 4 putative TMSs, where in each set, the last two TMSs are closs together. Caddeo et al. 2019 reported that the protein is anchored to the endo membrane via a 6 TMS domain. The predicted catalytic dyad of the protein, composed of the conserved asparagine in position 321 (Asn-321) and the preserved histidine in position 356 (His-356), has a lumenal localization. This is compatible with the role of MBOAT7 in remodeling the acyl chain composition of endomembranes. Obesity-linked suppression of MBOAT7 drives non-alcoholic fatty liver disease (Helsley et al. 2019). It may be involved in nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) (Di Sessa et al. 2021;Di Sessa et al. 2021; Longo et al. 2021).
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Accession Number: | Q96N66 |
Protein Name: | Lysophospholipid acyltransferase 7 |
Length: | 472 |
Molecular Weight: | 52765.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 9 |
Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MSPEEWTYLV VLLISIPIGF LFKKAGPGLK RWGAAAVGLG LTLFTCGPHT LHSLVTILGT
61: WALIQAQPCS CHALALAWTF SYLLFFRALS LLGLPTPTPF TNAVQLLLTL KLVSLASEVQ
121: DLHLAQRKEM ASGFSKGPTL GLLPDVPSLM ETLSYSYCYV GIMTGPFFRY RTYLDWLEQP
181: FPGAVPSLRP LLRRAWPAPL FGLLFLLSSH LFPLEAVRED AFYARPLPAR LFYMIPVFFA
241: FRMRFYVAWI AAECGCIAAG FGAYPVAAKA RAGGGPTLQC PPPSSPEKAA SLEYDYETIR
301: NIDCYSTDFC VRVRDGMRYW NMTVQWWLAQ YIYKSAPARS YVLRSAWTML LSAYWHGLHP
361: GYYLSFLTIP LCLAAEGRLE SALRGRLSPG GQKAWDWVHW FLKMRAYDYM CMGFVLLSLA
421: DTLRYWASIY FCIHFLALAA LGLGLALGGG SPSRRKAASQ PTSLAPEKLR EE