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2.A.50.2.5
MBOAT7, also called BB1, LENG4, OCT7, of 472 aas and possibly 12 TMSs as 3 sets of 4 putative TMSs, where in each set, the last two TMSs are closs together.  Caddeo et al. 2019 reported that the protein is anchored to the endo membrane via a 6 TMS domain. The predicted catalytic dyad of the protein, composed of the conserved asparagine in position 321 (Asn-321) and the preserved histidine in position 356 (His-356), has a lumenal localization. This is compatible with the role of MBOAT7 in remodeling the acyl chain composition of endomembranes. Obesity-linked suppression of MBOAT7 drives non-alcoholic fatty liver disease (Helsley et al. 2019). It may be involved in nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) (Di Sessa et al. 2021;Di Sessa et al. 2021; Longo et al. 2021).

Accession Number:Q96N66
Protein Name:Lysophospholipid acyltransferase 7
Length:472
Molecular Weight:52765.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPEEWTYLV VLLISIPIGF LFKKAGPGLK RWGAAAVGLG LTLFTCGPHT LHSLVTILGT 
61:	WALIQAQPCS CHALALAWTF SYLLFFRALS LLGLPTPTPF TNAVQLLLTL KLVSLASEVQ 
121:	DLHLAQRKEM ASGFSKGPTL GLLPDVPSLM ETLSYSYCYV GIMTGPFFRY RTYLDWLEQP 
181:	FPGAVPSLRP LLRRAWPAPL FGLLFLLSSH LFPLEAVRED AFYARPLPAR LFYMIPVFFA 
241:	FRMRFYVAWI AAECGCIAAG FGAYPVAAKA RAGGGPTLQC PPPSSPEKAA SLEYDYETIR 
301:	NIDCYSTDFC VRVRDGMRYW NMTVQWWLAQ YIYKSAPARS YVLRSAWTML LSAYWHGLHP 
361:	GYYLSFLTIP LCLAAEGRLE SALRGRLSPG GQKAWDWVHW FLKMRAYDYM CMGFVLLSLA 
421:	DTLRYWASIY FCIHFLALAA LGLGLALGGG SPSRRKAASQ PTSLAPEKLR EE