2.A.50.3.1
Porcupine, a protein-serine O-palmitoleoyltransferase
that acts as a key regulator of the Wnt signaling pathway by mediating
the attachment of palmitoleate, a 16-carbon mono-unsaturated fatty acid
(C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is
required for efficient binding to frizzled receptors (Caricasole et al. 2002; Coombs et al. 2010; Gao and Hannoush 2014). It also regulates the AMPA/TARP complex in a TARP-dependent manner (Kato and Witkin 2018).
|
| Accession Number: | Q9H237 |
|---|
| Protein Name: | Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Length: | 461 |
|---|
| Molecular Weight: | 52318.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 9 |
|---|
| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG
61: FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW
121: HKMRGAQMIV AMKAVSLGFD LDRGEVGTVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV
181: QGRPLSCRWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LNGDRLLRNK KRKARGTMVR
241: WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSKPL NVELPRSMVE
301: VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV
361: EHVLRKRLAR ILSACVLSKR CPPDCSHQHR LGLGVRALNL LFGALAIFHL AYLGSLFDVD
421: VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G