2.A.50.3.2
Porcupine (Por) of 525 aas and 9 - 11 TMSs. Por is a protein-serine O-palmitoleoyltransferase
that acts as a key regulator of the Wnt signaling pathway by mediating
the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid
(C16:1), to Wnt proteins. Serine palmitoleylation of Wnt proteins is
required for efficient binding to frizzled receptors (Herr and Basler 2012)
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| Accession Number: | Q9VWV9 |
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| Protein Name: | Protein-serine O-palmitoleoyltransferase porcupine |
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| Length: | 525 |
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| Molecular Weight: | 59195.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MDYQYFEEES DYIDLDEEEE DDDVVTAGSL DHRFGQPNGE EDYYFGGDDV EEELVVDGHG
61: VLELAGRLLE SLQSCVQPSV LQVMQYVAPM LLLCLLCRLL CLLYSQRRRL TSLAPLHLFH
121: FACGLIILQI TVGYRLLLLL LLAAVGYLLL QLLRLGRRGA QVLAVLTVGS QFLYELLIWR
181: RRSDWPQLRG IQMVVNMKLI SLGFDLTASG QLQARIPGPF AYLGYIYSPA TCALGPWVSF
241: GCYMDCLVPR NSWLVSLRRL LPNVVICVLA VTVSNCVAPA LSDFFGDSSH FLVMYWDALS
301: VRSSHYFVGM MAQALLVASD QRLDGATKES DMLGPLISQP WRIEWPRSIS SLVRSWNIPM
361: HEWLKRYIYA PCKPTASTSR GRILVVVLST YLVSSLLHGM DLRIYLVLIS LAFLAEGESL
421: LRRQLASLLN ACITANLCPG KERCRYSHCP SKRRLNSLSY WLARLTNLAF TALAIFHLAY
481: LGVVLLGDDL EVGEDGDSFL WHWQQAGYLS HYIGLGTFVL YLFIS