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2.A.59.1.1
Plasma membrane ACR3 arsenite exporter (AsIII:H+ antiporter) (Wysocki et al., 1997).  Catalyzes proton antiport with either arsenite or antimonite.  Cys151 is essential for transport activity, while Cys90 and Cys169 are important in trafficking (Maciaszczyk-Dziubinska et al. 2013).  Other residues important for folding, trafficking and/or activity have also been identified (Markowska et al. 2015). This protein has 10 TMSs with cytoplasmically oriented N- and C-termini, and a homology-based structural model of Acr3 using the crystal structure of the Yersinia frederiksenii homologue of the human bile acid sodium symporter, ASBT, has been constructed (Wawrzycka et al. 2016).

Accession Number:Q06598
Protein Name:ACR3 aka ARR3 aka YPR201W aka P9677.2
Length:404
Molecular Weight:45848.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate arsenite, H+

Cross database links:

DIP: DIP-3797N
RefSeq: NP_015527.1   
Entrez Gene ID: 856331   
Pfam: PF01758   
KEGG: sce:YPR201W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015105 F:arsenite transmembrane transporter activity
GO:0008508 F:bile acid:sodium symporter activity
GO:0005515 F:protein binding
GO:0015700 P:arsenite transport
GO:0046685 P:response to arsenic
GO:0006814 P:sodium ion transport

References (2)

[1] “Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae.”  Bobrowicz P.et.al.   9234670
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEDQKSENS VPSKVNMVNR TDILTTIKSL SWLDLMLPFT IILSIIIAVI ISVYVPSSRH 
61:	TFDAEGHPNL MGVSIPLTVG MIVMMIPPIC KVSWESIHKY FYRSYIRKQL ALSLFLNWVI 
121:	GPLLMTALAW MALFDYKEYR QGIIMIGVAR CIAMVLIWNQ IAGGDNDLCV VLVITNSLLQ 
181:	MVLYAPLQIF YCYVISHDHL NTSNRVLFEE VAKSVGVFLG IPLGIGIIIR LGSLTIAGKS 
241:	NYEKYILRFI SPWAMIGFHY TLFVIFISRG YQFIHEIGSA ILCFVPLVLY FFIAWFLTFA 
301:	LMRYLSISRS DTQRECSCDQ ELLLKRVWGR KSCEASFSIT MTQCFTMASN NFELSLAIAI 
361:	SLYGNNSKQA IAATFGPLLE VPILLILAIV ARILKPYYIW NNRN