| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
2.A.59.1.1 | Plasma membrane ACR3 arsenite exporter (AsIII:H+ antiporter) (Wysocki et al., 1997). Catalyzes proton antiport with either arsenite or antimonite. Cys151 is essential for transport activity, while Cys90 and Cys169 are important in trafficking (Maciaszczyk-Dziubinska et al. 2013). Other residues important for folding, trafficking and/or activity have also been identified (Markowska et al. 2015). This protein has 10 TMSs with cytoplasmically oriented N- and C-termini, and a homology-based structural model of Acr3 using the crystal structure of the Yersinia frederiksenii homologue of the human bile acid sodium symporter, ASBT, has been constructed (Wawrzycka et al. 2016). | Eukaryota |
Fungi, Ascomycota | ACR3 of Saccharomyces cerevisiae |
|
2.A.59.1.2 | ArsB arsenite/antimonite exporter (Sato and Kobayashi, 1998) | Bacteria |
Bacillota | ArsB of Bacillus subtilis (spP45946) |
|
2.A.59.1.3 | The arsenical resistance membrane protein, the arsenate (not arsenite) transporter, So_ACR3 (Xia et al., 2008) (with 7 putative TMSs and an N-terminus in the periplasm). | Bacteria |
Pseudomonadota | ACR3 of Shewanella oneidensis (Q8EJD3) |
|
2.A.59.1.4 | Arc3 homologue | Archaea |
Euryarchaeota | Acr3 of Pyrococcus furiosus (Q8U3B8) |
|
2.A.59.1.5 | The arsenite-specific exporter, Acr3/ArsA1/ArsA2. ArsA1 and ArsA2 are half sized ATPases (Fu et al., 2010). | Bacteria |
Bacillota | The Acr3/ArsA1/ArsA2 arsenite exporter of Alkaliphilus metalliredigens Acr3 (A6TP80) ArsA1 (A6TP82) ArsA2 (A6TP83) |
|
2.A.59.1.6 | The arsenite-specific exporter, Acr3'/ArsA1'/ArsA2'. ArsA1' and ArsA2' are half sized ATPases (Fu et al., 2009; 2010) | Bacteria |
Bacillota | The Acr3'/ArsA1'/ArsA2' arsenite exporter of Alkaliphilus metalliredigens Acr3' (A6TLY3) ArsA1' (A6TLY5) ArsA2' (A6TLY6) |
|
2.A.59.1.7 | Aresenite (AsIII):H+ antiporter, Acr3-1; confers resistance to As(III) but not Sb(III) (antimonite) (Villadangos et al. 2012; Yang et al. 2012). | Bacteria |
Actinomycetota | Acr3-1 of Corynebacterium glutamicum |
|
2.A.59.2.1 | Putative efflux pump (Acr3) | Bacteria |
Pseudomonadota | Acr3 of Sulfitobacter sp. NAS-14.1 (A3T1V5)
|
|
2.A.59.2.2 | Acr3 homologue of unknown function (10 putative TMSs) | Bacteria |
Chloroflexota | Acr3 of Chloroflexus aggregans (B8GAD2)
|