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Accession Number: | Q9UHC9 |
Protein Name: | Niemann-Pick C1-like protein 1 |
Length: | 1359 |
Molecular Weight: | 148698.00 |
Species: | Homo sapeins [9606] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Multi-pass membrane protein2 |
Substrate | lipid, cholesterol, sterol, lutein |
Cross database links:
RefSeq: | NP_001095118.1 NP_037521.2 |
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Entrez Gene ID: | 29881 |
Pfam: | PF02460 |
OMIM: |
608010 gene+phenotype |
KEGG: | hsa:29881 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0030659
C:cytoplasmic vesicle membrane
GO:0016021
C:integral to membrane
GO:0008158
F:hedgehog receptor activity
GO:0006695
P:cholesterol biosynthetic process
GO:0030299
P:intestinal cholesterol absorption
GO:0042157
P:lipoprotein metabolic process
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References (7)[1] “Evidence for a Niemann-Pick C (NPC) gene family: identification and characterization of NPC1L1.” Davies J.P.et.al. 10783261 [2] “Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption.” Altmann S.W.et.al. 14976318 [3] “Human chromosome 7: DNA sequence and biology.” Scherer S.W.et.al. 12690205 [4] “Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.” Davies J.P.et.al. 15671032 [5] “Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.” van der Veen J.N.et.al. 15604518 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MAEAGLRGWL LWALLLRLAQ SEPYTTIHQP GYCAFYDECG KNPELSGSLM TLSNVSCLSN 61: TPARKITGDH LILLQKICPR LYTGPNTQAC CSAKQLVSLE ASLSITKALL TRCPACSDNF 121: VNLHCHNTCS PNQSLFINVT RVAQLGAGQL PAVVAYEAFY QHSFAEQSYD SCSRVRVPAA 181: ATLAVGTMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV 241: ARCNESQGDD VATCSCQDCA ASCPAIARPQ ALDSTFYLGQ MPGSLVLIII LCSVFAVVTI 301: LLVGFRVAPA RDKSKMVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS WPLTILVLSV 361: IPVVALAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH FGPFFRTNQV ILTAPNRSSY 421: RYDSLLLGPK NFSGILDLDL LLELLELQER LRHLQVWSPE AQRNISLQDI CYAPLNPDNT 481: SLYDCCINSL LQYFQNNRTL LLLTANQTLM GQTSQVDWKD HFLYCANAPL TFKDGTALAL 541: SCMADYGAPV FPFLAIGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAK LWEEAFLEEM 601: RAFQRRMAGM FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA LGSYSSWSRV 661: MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLVILQ VVPFLVLSVG ADNIFIFVLE 721: YQRLPRRPGE PREVHIGRAL GRVAPSMLLC SLSEAICFFL GALTPMPAVR TFALTSGLAV 781: ILDFLLQMSA FVALLSLDSK RQEASRLDVC CCVKPQELPP PGQGEGLLLG FFQKAYAPFL 841: LHWITRGVVL LLFLALFGVS LYSMCHISVG LDQELALPKD SYLLDYFLFL NRYFEVGAPV 901: YFVTTLGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA SSWVDDFIDW 961: LTPSSCCRLY ISGPNKDKFC PSTVNSLNCL KNCMSITMGS VRPSVEQFHK YLPWFLNDRP 1021: NIKCPKGGLA AYSTSVNLTS DGQVLDTVAI LSPRLEYSGT ISAHCNLYLL DSASRFMAYH 1081: KPLKNSQDYT EALRAARELA ANITADLRKV PGTDPAFEVF PYTITNVFYE QYLTILPEGL 1141: FMLSLCLVPT FAVSCLLLGL DLRSGLLNLL SIVMILVDTV GFMALWGISY NAVSLINLVS 1201: AVGMSVEFVS HITRSFAIST KPTWLERAKE ATISMGSAVF AGVAMTNLPG ILVLGLAKAQ 1261: LIQIFFFRLN LLITLLGLLH GLVFLPVILS YVGPDVNPAL ALEQKRAEEA VAAVMVASCP 1321: NHPSRVSTAD NIYVNHSFEG SIKGAGAISN FLPNNGRQF