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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
2.A.67.1.1	Oligopeptide transporter, OPT1	Eukaryota	Fungi, Ascomycota	OPT1 of Candida albicans
2.A.67.1.2	Sexual differentiation process, ISP4 protein (tetra peptide transporter)	Eukaryota	Fungi, Ascomycota	ISP4 of Schizosaccharomyces pombe
2.A.67.1.3	The YJL212c gene protein (oligopeptide transporter, Opt1p; transports the mammalian pentapeptide, enkephalin, and the tripeptide, glutathione)	Eukaryota	Fungi, Ascomycota	Opt1p (YJL212c) of Saccharomyces cerevisiae
2.A.67.1.4	High affinity glutathione uptake porter, Hgt1p or OPT2 of 877 aas and ~12 TMSs in a 6 + 6 TMS arrangement. TMS 9 plays a role in glutathione recognition (Thakur & Bachhawat et al., 2010; Thakur and Bachhawat 2015). OPT2 shows highest affinity for reduced glutathione but also transports oxidized glutathione and glutathione conjugates with lesser affinities (Zulkifli et al. 2016). Residues have been identified that are essential for H⁺-dependent glutathione uptake (Zulkifli and Bachhawat 2017). OPT2 is upregulated to facilitate the uptake of oligopeptide and amino acid into yeast cells (Zhu et al. 2023).	Eukaryota	Fungi, Ascomycota	Hgt1p of Saccharomyces cerevisiae (Q06593)
2.A.67.1.5	The glutathione (tripeptide) uptake transporter, Opt1 or Pgt1 (Dworeck et al., 2009). Transports γ-Glu-Cys-Gly and Glu-Cys-Gly (Thakur et al., 2008). Mutations in the N-terminus allow functional expression in S. cerevisiae (Thakur and Bachhawat 2013).	Eukaryota	Fungi, Ascomycota	Opt1 of Schizosaccharomyces pombe (O14031)
2.A.67.1.6	Tetra or penta oligopeptide uptake transporter OPT9 (highly expressed in microspores and bipolar pollen; Bock et al., 2006)	Eukaryota	Viridiplantae, Streptophyta	OPT9 of Arabidopsis thaliana (Q9FJD2)
2.A.67.1.7	Oligopeptide transporter 3, Opt3, of 737 aas and 15 - 17 TMSs (Koh et al. 2002). It may be involved in the translocation of tetra- and pentapeptides across the cellular membrane, but it also acts as a metal transporter as a component capable of transporting Fe²⁺ and/or Cu²⁺ (Wintz et al. 2003). It is essential for early embryo development in Arabidopsis (Stacey et al. 2002). OPT3 proteins are involved in ROS regulation, plant stress responses, and basal pathogen resistance. The transport of iron through OPT3s may occur with glutathione (GSH) (Kurt 2021).	Eukaryota	Viridiplantae, Streptophyta	Opt3 of Arabidopsis thaliana (Mouse-ear cress)
2.A.67.2.1	'Yellow Stripe1' (YS1) Fe³⁺-phyto siderophore:H⁺ symporter. It takes up various metal cations (Fe³⁺, Zn²⁺, Cu²⁺, Ni²⁺, Mn²⁺ and Cd²⁺ when complexed with phytosiderophores, and Ni²⁺, Fe²⁺ and Fe³⁺ when complexed with nicotinamine) (Curie et al., 2001; Schaaf et al., 2004)	Eukaryota	Viridiplantae, Streptophyta	YS1 of Zea mays
2.A.67.2.2	The metal (iron, copper, and zinc) nicotinamide transporter, YSL1 (Waters et al., 2006) (57% identity with YS1). YSL1 and YSL3 function in the delivery of metal micronutrients to and from vascular tissues.	Eukaryota	Viridiplantae, Streptophyta	YSL1 of Arabidopsis thaliana (Q6R3L0)
2.A.67.2.3	The metal (iron and copper)-nicotinamide transporter, YSL2 (mediates lateral movement of metals in the vasculature; DiDonato et al., 2004) (62% identity with YS1).	Eukaryota	Viridiplantae, Streptophyta	YSL2 of Arabidopsis thaliana (Q6R3K9)
2.A.67.2.4	The probable metal (iron, copper, and zinc)-nicotinamide transporter, YSL3; functionally redundant with YSL1 (Waters et al., 2006).	Eukaryota	Viridiplantae, Streptophyta	YSL3 of Arabidopsis thaliana (Q2EF88)
2.A.67.2.5	The rice iron(III)-deoxymugineic acid transporter, YSL18 (specifically expressed in reproductive organs and phloem of lamina joints) (Aoyama et al., 2009).	Eukaryota	Viridiplantae, Streptophyta	YSL18 of Oryza sativa (Q941V3)
2.A.67.2.6	OPT family member	Eukaryota	Evosea	OPT family homologue of Dictyostelium discoideum (Q54EF1)
2.A.67.2.7	Putative oligopeptide transporter YGL114W	Eukaryota	Fungi, Ascomycota	YGL114W of Saccharomyces cerevisiae
2.A.67.2.8	The metal-phytosiderophore complex transporter, HvYSL2 (Araki et al. 2011).	Eukaryota	Viridiplantae, Streptophyta	HvYSL2 of Hordeum vulgare
2.A.67.2.9	Yellow stripe-like 7 protein, YSL7; expression gives rise to heavy metal tolerance in Brassica juncea (Wang et al. 2013).	Eukaryota	Viridiplantae, Streptophyta	YSL7 in Arabidopsis thaliana
2.A.67.2.10	Ferric (Fe³⁺)-phytosiderophore uptake mediator (Yellow stripe like transporter) of 600 aas and 12 TMSs. The outer membrane loop between the sixth and seventh transmembrane regions is essential for substrate specificity. A synthetic peptide corresponding to the loop of HvYS1 forms an alpha-helix in solution, whereas that of the corn orthologue, ZmYS1, is flexible. Harada et al. 2007 proposed that this structural difference determines the narrow substrate specificity of HvYS1 compared to that of ZmYS1 which is of broad specificity.	Eukaryota	Viridiplantae, Streptophyta	HvYS1 of Hordeum vulgare (Barley)
2.A.67.2.11	Ysl2 of 674 aas and 14 TMSs. OsYSL2 is a rice metal-nicotianamine transporter that is regulated by iron and expressed in the phloem (Koike et al. 2004). Methyl jasmonate increased Fe accumulation in leaves by increasing expression of FRDL1 (a member of the Mop family (TC# 2.A.66) and YSL2 transporters under arsenate toxicity (Mousavi et al. 2020).	Eukaryota	Viridiplantae, Streptophyta	YSL2 of Oryza sativa (rice)
2.A.67.3.1	Early sporulation protein, EspB (temporal control protein)	Bacteria	Myxococcota	EspB of Myxococcus xanthus
2.A.67.4.1	Orf HI0561/560	Bacteria	Pseudomonadota	Orf of Haemophilus influenzae
2.A.67.4.2	OPT family member	Archaea	Euryarchaeota	OPT family member from Pyrococcus horikoshii (O58099)
2.A.67.4.3	OPT family member	Bacteria	Pseudomonadota	OPT protein of Caulobacter crescentus (Q9A523)
2.A.67.5.1	Putative oligopeptide transporter	Bacteria	Myxococcota	Putative oligopeptide transporter of Myxococcus xanthus