2.A.7.1.1
Small multidrug efflux pump, Smr (QacC, QacD, Ebr). Substrates: (1) aromatic dyes (e.g., ethidium bromide), (2) quaternary amines (e.g., the disinfectant benzalkonium) and (3) derivatives of tetraphenylphosphonium (TPP) (Fuentes et al. 2005). Unassembled monomers of the SMR family exist in a dynamic equilibrium where the N-terminal TMS flips in and out of the membrane, with rates that depend on dimerization and the polypeptide sequence (Seurig et al. 2019).
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| Accession Number: | P14319 |
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| Protein Name: | QACC aka Smr aka EBR |
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| Length: | 107 |
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| Molecular Weight: | 11673.00 |
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| Species: | Staphylococcus aureus [1280] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
quaternary ammonium ion |
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| RefSeq: |
NP_863640.1
NP_878005.1
YP_534903.1
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| Entrez Gene ID: |
2598266
2598368
3978602
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| Pfam: |
PF00893
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[1] “Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus.” Sasatsu M. et.al. 2602117
[2] “A staphylococcal multidrug resistance gene product is a member of a new protein family.” Grinius L. et.al. 1615062
[3] “Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus.” Littlejohn T.G. et.al. 1840534
[4] “High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus.” Sasatsu M. et.al. 1505735
[5] “Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.” Tennent J.M. et.al. 2778425
[6] “Molecular characterization of the staphylococcal multidrug resistance export protein QacC.” Paulsen I.T. et.al. 7751293
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1: MPYIYLIIAI STEVIGSAFL KSSEGFSKFI PSLGTIISFG ICFYFLSKTM QHLPLNITYA
61: TWAGLGLVLT TVVSIIIFKE QINLITIVSI VLIIVGVVSL NIFGTSH