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2.A.7.10.2
The bifunctional ER-Golgi nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine, SLC35B4 (Ashikov et al., 2005) for glycosylation. SLC35B4 plays a role in hepatocellular carcinoma (HCC) tumorigenesis (Jiang et al. 2022). The expression levels of SLC35B4 are higher in HCC tissues than adjacent non-tumor tissues, and SLC35B4 is important for the proliferation and tumorigenesis of HCC cells. Mechanistically, SLC35B4 is important for the O-GlcNAc modification of c-Myc and thus the stabilization of c-Myc, which is required for HCC tumorigenesis (Jiang et al. 2022). 

Accession Number:Q969S0
Protein Name:UDP-xylose and UDP-N-acetylglucosamine transporter
Length:331
Molecular Weight:37424.00
Species: [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate UDP-N-acetyl-alpha-D-glucosamine, UDP-alpha-D-xylose

Cross database links:

RefSeq: NP_116215.1   
Entrez Gene ID: 84912   
Pfam: PF08449   
OMIM: 610923  gene
KEGG: hsa:84912    hsa:84912   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005462 F:UDP-N-acetylglucosamine transmembrane trans...
GO:0005464 F:UDP-xylose transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0015788 P:UDP-N-acetylglucosamine transport
GO:0015790 P:UDP-xylose transport
GO:0005462 F:UDP-N-acetylglucosamine transmembrane transporter activity

References (12)

[1] “The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.”  Ashikov A.et.al.   15911612
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[4] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[5] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.”  Ashikov A.et.al.   15911612
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[10] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[11] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF EADLGRKPPA 
61:	IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSIFK 
121:	YTSIALVSVG IFICTFMSAK QVTSQSSLSE NDGFQAFVWW LLGIGALTFA LLMSARMGIF 
181:	QETLYKRFGK HSKEALFYNH ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW 
241:	FYLLMNIITQ YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT 
301:	LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N