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2.A.7.11.1
Possible UDP-galactose:UMP and documented ATP/ADP exchanger (antiporter).  Residues essential or important for activity have been identified (Chan et al. 2010). The apparent affinities of SLC35B1 for ATP/ADP on the internal face were approximately 13 times higher than those on the external side (Schwarzbaum et al. 2022). ATP/ADP exchange by SLC35B1 is not strict; other di- and trinucleotides can act as counter-substrates for ATP, although mononucleotides and nucleotide sugars were not transported. Conserved residues K117 and K120 in TMS 4 and K277 in TMS 9 play critical roles in transport. The fact that SLC35B1 can promote ATP transport in exchange for ADP or UDP suggests a more direct coupling between ATP import requirements and the need for eliminating ADP and UDP, which are generated as side products of reactions taking place in the ER-lumen (Schwarzbaum et al. 2022).

Accession Number:P78383
Protein Name:UGTrel1
Length:322
Molecular Weight:35760.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate ADP, ATP, GDP, GTP, UDP, UTP, UDP-alpha-D-galactose

Cross database links:

RefSeq: NP_005818.1   
Entrez Gene ID: 10237   
Pfam: PF08449   
OMIM: 610790  gene
KEGG: hsa:10237    hsa:10237   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005792 C:microsome
GO:0005459 F:UDP-galactose transmembrane transporter act...
GO:0008643 P:carbohydrate transport
GO:0055085 P:transmembrane transport
GO:0005459 F:UDP-galactose transmembrane transporter activity

References (4)

[1] “Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.”  Ishida N.et.al.   9010752
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.”  Ishida N.et.al.   9010752
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASSSSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGAKQETFT FALTLVFIQC 
61:	VINAVFAKIL IQFFDTARVD RTRSWLYAAC SISYLGAMVS SNSALQFVNY PTQVLGKSCK 
121:	PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG VALFMYKPKK VVGIEEHTVG YGELLLLLSL 
181:	TLDGLTGVSQ DHMRAHYQTG SNHMMLNINL WSTLLLGMGI LFTGELWEFL SFAERYPAII 
241:	YNILLFGLTS ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISPMQWVGT 
301:	VLVFLGLGLD AKFGKGAKKT SH