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2.A.7.11.5
SLC35B3 translocates adenosine 3'-phosphate 5'-phosphosulfate, PAPS, the high-energy sulfate donor from the cytosol to the Golgi lumen for sulfation of glycoproteins, proteoglycans and glycolipids (Kamiyama et al. 2006). It is encoded by a gene in a signature gene set that serves as a simple proxy as a promising biomarker to predict chemoresponsiveness of muscle-invasive bladder cancer (MIBC) patients (Hepburn et al. 2021).

Accession Number:Q9H1N7
Protein Name:Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Length:401
Molecular Weight:44593.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_001136012.1    NP_001136013.1    NP_057032.2   
Entrez Gene ID: 51000   
Pfam: PF08449   
OMIM: 610845  gene
KEGG: hsa:51000    hsa:51000   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport
GO:0005739 C:mitochondrion

References (10)

[1] “Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.”  Kamiyama S.et.al.   16492677
[2] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.”  Lai C.-H.et.al.   10810093
[3] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[4] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.”  Kamiyama S.et.al.   16492677
[7] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.”  Lai C.-H.et.al.   10810093
[8] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[9] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDLTQQAKDI QNITVQETNK NNSESIECSK ITMDLKFNNS RKYISITVPS KTQTMSPHIK 
61:	SVDDVVVLGM NLSKFNKLTQ FFICVAGVFV FYLIYGYLQE LIFSVEGFKS CGWYLTLVQF 
121:	AFYSIFGLIE LQLIQDKRRR IPGKTYMIIA FLTVGTMGLS NTSLGYLNYP TQVIFKCCKL 
181:	IPVMLGGVFI QGKRYNVADV SAAICMSLGL IWFTLADSTT APNFNLTGVV LISLALCADA 
241:	VIGNVQEKAM KLHNASNSEM VLYSYSIGFV YILLGLTCTS GLGPAVTFCA KNPVRTYGYA 
301:	FLFSLTGYFG ISFVLALIKI FGALIAVTVT TGRKAMTIVL SFIFFAKPFT FQYVWSGLLV 
361:	VLGIFLNVYS KNMDKIRLPS LYDLINKSVE ARKSRTLAQT V