2.A.7.15.5
The putative Golgi nucleotide-sugar transporter SLC35D3 (416aas, 10 TMSs) (Chintala et al. 2007).  SLC35D3 regulates tissue-specific autophagy and plays an important role in the increased autophagic activity required for the survival of subsets of dopaminergic neurons (Wei et al. 2016). SLC35D3 silenced cells show increased expression of genes related to fat synthesis, and increased deposition of intramuscular fat,  an abundance of lipid droplets, and an increased level of free fatty acid in the culture medium. In contrast, the siRNA decreased the expression of genes involved in fat catabolism (Li et al. 2020), suggesting a role in the transport of fatty acids or their derivatives. It may play a role during porcine intramuscular preadipocyte differentiation (Li et al. 2020).