2.A.7.19.4
Ureide permease 2, UPS2, of 398 aas and 10 TMSs. Proton-coupled transporter that transports a
wide spectrum of oxo derivatives of heterocyclic nitrogen compounds,
including allantoin, uric acid and xanthine, but not adenine. Mediates
high affinity transport of uracil and 5-fluorouracil (a toxic uracil
analog). Mediates transport of free pyrimidines and may function during
early seedling development in salvage pathways, by the utilization of
pyrimidines from seed storage tissue (Schmidt et al. 2004). Km for uracil = 6 μM; for xanthine = 24 μM; for allantoin = 26 μM.
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| Accession Number: | Q9ZQ89 |
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| Protein Name: | Ureide permease 2 |
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| Length: | 398 |
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| Molecular Weight: | 43542.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
allantoin, pyrimidine, uracil, 5-fluorouracil, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, 9H-xanthine |
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1: MYLVESKGGA IACMLLALLS LGTWPAVLTL LERRGRLPQH TYLDYSITNL LAAIIIAFTF
61: GQIGSTKPDS PNFITQLAQD NWPSVMFAMA GGIVLSLGNL STQYAWALVG LSVTEVITSS
121: ITVVIGSTLN YFLDDKINKA EILFPGVACF LIAVCLGSAV HRSNADDNKA KLRDFETAKQ
181: EASGPSTEIG TNSSKDLETN VTTKPKEGTA RFLIELENTR AIKVFGKRKI IGLAITFFAG
241: LCFSLFSPAF NLATNDQWNR LKQGVPKLVV YTAFFYFSVS CFIIALILNV VFLYYPVLGL
301: PKSSFKAYLN DWNGRYWAFL AGFLCGFGNG LQFMGGQAAG YAAADSVQAL PLVSTFWGVV
361: LFGEYRRSSR KTYLLLFCML FMFISAVAVL MASSGHRK