2.A.7.25.9
Magnesium transporter NIPA3; NIPAL1; NPAL1; SLC57A3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3 homologue). It is a Mg2+ transporter that can also transport Sr2+, Ba2+, Fe2+ and Cu2+ (Gyimesi and Hediger 2022). The human ortholog is 87% identical to the mouse protein.
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| Accession Number: | Q8BMW7 |
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| Protein Name: | Magnesium transporter NIPA3 |
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| Length: | 416 |
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| Molecular Weight: | 45159.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
magnesium(2+) |
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| Entrez Gene ID: |
70701
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| Pfam: |
PF05653
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| KEGG: |
mmu:70701
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[1] “The transcriptional landscape of the mammalian genome.” Carninci P. et.al. 16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.” Church D.M. et.al. 19468303
[3] “Functional characterization of NIPA2, a selective Mg2+ transporter.” Goytain A. et.al. 18667602
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1: MGVQLRLPPG EPCHEGYVLS LVCSNSSRAS CEITNVSESL PYPVVYTNLN SSKTNFSISA
61: SVENKYNLYV GLVLAISSSV FIGSSFILKK KGLLQLADKG ITRAGQGGHS YLKEWLWWAG
121: LLSMGAGEAA NFAAYAFAPA TLVTPLGALS VLISAILSSY FLNERLNIHG KIGCILSVLG
181: STVMVIHAPQ EGEVTSLHEM EMKLRDPGFV SFAVIISVIS LVLILIVAPK KGQTNILVYI
241: AICSLIGAFS VSSVKGLGIA IKELLERKPV YKDPLFFILL TMLALSVTTQ INYLNKALDT
301: FNTSLVTPIY YVFFTSMVVT CSAILFQEWY GMKAGDIIGT LSGFFTIING IFLLHAFKNT
361: NITWSELMST AKKEALSPNG NQNSYVLLEN ADFSASGYDD DITLFSRTND QSSHKL