2.A.7.32.6
TMEM234 of 234 aas and 4 TMSs in a 1 + 3 TMS arrangement. In zebrafish larvae, Tmem234 is essential for the
organization and functional integrity of the pronephric glomerulus
filtration barrier. Inactivation of Tmem234 expression results in
foot process effacement and proteinuria. It is one of
four highly podocyte-enriched proteins.
Tmem234 is essential for the normal filtration barrier in the zebrafish
pronephric glomerulus (Rodriguez et al. 2015).
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| Accession Number: | B8A4M2 |
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| Protein Name: | Transmembrane protein 234 |
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| Length: | 143 |
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| Molecular Weight: | 15550.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
|
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1: MVSTSEVFCL LLVAILWGGT NPFLKKGTEG IEEVQKKNKL LQFLAELKFL FLNFKYLVPF
61: LLNQSGSLVF YFTLASTDLS LAVPVVNSLT FLFTLLMGKV LGEEFGGKGA IMGMLLIMCG
121: VTVCVLSSVS ETHGIGARNI SET