2.A.7.9.24 The phosphoenolpyruvate/phosphate translocator, pPT, of 524 aas in the outer membranes of apicoplasts, vestigial plastids in apicomplexan parasites such as Plasmodium. Transports glucose-6 P and triose-3 Ps via an inorganic phosphate antiport mechanism. Apicomplexan parasites are dependant on their apicoplasts for synthesis of various
molecules that they are unable to scavenge in sufficient quantity from their host. They import carbon, energy and
reducing power to drive anabolic synthesis in the organelle. pPT is targeted
into the outer apicoplast membrane via a
transmembrane domain that acts as a recessed signal anchor to direct the protein into the
endomembrane system. A tyrosine in the cytosolic N-terminus of the protein is essential for
targeting (Lim et al. 2016).
|
Accession Number: | Q8I0U9 |
Protein Name: | Phosphoenolpyruvate/phosphate translocator |
Length: | 524 |
Molecular Weight: | 59789.00 |
Species: | Plasmodium falciparum (isolate 3D7) [36329] |
Number of TMSs: | 9 |
Substrate |
phosphoenolpyruvate, phosphate(3-) |
---|
1: MNVLTRTLII TIFFNLQIYI GKCLNHDNIK NIKNVPMNFH LKNTNGKIYQ KNKRPSQINR
61: KNTNKQAFNI PVFSIPNYKP KYNTCTKTKN IAFVNSRINQ AHNRNIQVTK AAELNAIKKI
121: KNDKKFTLFN SGNRDNIKTY EHDINKGIID DISTTNNSYS NIGDTSENTY QPNNFNNTLT
181: EKKPCTFLNK AVEVGKTVSL LGMWYVCNIF YNIENKKALN ILNMPITIAI TQIYVGLPIF
241: LIPWLLKLRN QPELFYDEQE LKRINMSDRN ALIKGFQKYV LFLKKYSSIM KQSIYHGYAH
301: LLSVIAMGAG AISFVHIVKA SAPLFAAFFS YFFMNNKMSI YTYSSLVPIV FGVSLASIKE
361: LSFTYKALYS TLSANVLSTM RAIEAKIMMG KNLDKLGRNL TPENIFALLT LSSAIFLTPA
421: LYIDSHKWKD AYEYLMNNKN VLKVLGRHVL MSGVWFYLYN QLSFISLNRL NHITHAVAST
481: VKRVFLILTS YFIFGTKFSF LGGLGSSIAV GGTFVYSLVK KKFG