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2.A.76.1.1 Homoserine/homoserine lactone/β-hydroxynorvaline efflux permease (probable substrate:H⁺ antiporter), RhtB (YigK). Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).
Accession Number:	P0AG34
Protein Name:	Homoserine/homoserine lactone efflux protein RhtB aka B3824
Length:	206
Molecular Weight:	22427.00
Species:	Escherichia coli [83333]
Number of TMSs:	6
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	homoserine, homoserine lactone

RefSeq:	AP_003976.1 YP_026265.1
Entrez Gene ID:	948316
Pfam:	PF01810
BioCyc:	EcoCyc:RHTB-MONOMER
KEGG:	ecj:JW5585 eco:b3824
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0006865 P:amino acid transport
References (5) [1] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.” Daniels D.L.et.al. 1379743 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.” Riley M.et.al. 16397293 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “The novel transmembrane Escherichia coli proteins involved in the amino acid efflux.” Zakataeva N.P.et.al. 10386596

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTLEWWFAYL LTSIILSLSP GSGAINTMTT SLNHGYRGAV ASIAGLQTGL AIHIVLVGVG 
61:	LGTLFSRSVI AFEVLKWAGA AYLIWLGIQQ WRAAGAIDLK SLASTQSRRH LFQRAVFVNL 
121:	TNPKSIVFLA ALFPQFIMPQ QPQLMQYIVL GVTTIVVDII VMIGYATLAQ RIALWIKGPK 
181:	QMKALNKIFG SLFMLVGALL ASARHA

2.A.76.1.1
Homoserine/homoserine lactone/β-hydroxynorvaline efflux permease (probable substrate:H⁺ antiporter), RhtB (YigK). Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Cross database links:

Gene Ontology

References (5)

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2.A.76.1.1Homoserine/homoserine lactone/β-hydroxynorvaline efflux permease (probable substrate:H+ antiporter), RhtB (YigK). Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.76.1.1
Homoserine/homoserine lactone/β-hydroxynorvaline efflux permease (probable substrate:H⁺ antiporter), RhtB (YigK). Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005).