2.A.76.1.2
Threonine efflux permease (probable threonine:H+ antiporter), RhtC (YigJ). Expression is under the control of the leucine-responsive protein, Lrp, and amino acids in the medium (Kutukova et al. 2005). Mutation of the rhtC gene can protect cells against toxic levels of threonine (Radi et al. 2022).
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| Accession Number: | P0AG38 |
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| Protein Name: | Threonine efflux protein RhtC aka YigJ aka B3823 |
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| Length: | 206 |
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| Molecular Weight: | 22474.00 |
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| Species: | Escherichia coli [83333] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
hydron, L-threonine |
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| RefSeq: |
AP_003977.1
YP_026264.1
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| Entrez Gene ID: |
948317
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| Pfam: |
PF01810
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| BioCyc: |
EcoCyc:RHTC-MONOMER
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| KEGG: |
ecj:JW5586
eco:b3823
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[1] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.” Daniels D.L. et.al. 1379743
[2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R. et.al. 9278503
[3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.” Riley M. et.al. 16397293
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K. et.al. 16738553
[5] “The recQ gene of Escherichia coli K12: primary structure and evidence for SOS regulation.” Irino N. et.al. 3027506
[6] “The novel transmembrane Escherichia coli proteins involved in the amino acid efflux.” Zakataeva N.P. et.al. 10386596
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O. et.al. 15919996
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1: MLMLFLTVAM VHIVALMSPG PDFFFVSQTA VSRSRKEAMM GVLGITCGVM VWAGIALLGL
61: HLIIEKMAWL HTLIMVGGGL YLCWMGYQML RGALKKEAVS APAPQVELAK SGRSFLKGLL
121: TNLANPKAII YFGSVFSLFV GDNVGTTARW GIFALIIVET LAWFTVVASL FALPQMRRGY
181: QRLAKWIDGF AGALFAGFGI HLIISR